Talk:Omeprazole

Pharmacodynamics

This section is actually describing clinical pharmacokinetics. Needs to describe mechanism of the drug, e.g. proton pump inhibitor. Receptor binding, etc. Times to onset, duration, peak effect are kinetic parameters. 121.75.48.151 (talk) 18:51, 18 March 2016 (UTC)

Cytochrome P450 system

"Omeprazole is completely metabolized by the cytochrome P450 system, mainly in the liver. Identified metabolites are the sulfone, the sulfide, and hydroxy-omeprazole, which exert no significant effect on acid secretion. About 80% of an orally given dose is excreted as metabolites in the urine, and the remainder is found in the feces, primarily originating from bile secretion."

This should be more specific. And a source is missing!

"CYP2C19 is the principal enzyme that metabolizes omeprazole to inactive metabolites."

source: https://www.ncbi.nlm.nih.gov/books/NBK100895/
--85.176.29.147 (talk) 19:55, 28 March 2018 (UTC)

CH3-Group added?

In 'Pharmacology' a CH3 group is added to the pyridine structure. Is this (unmentioned) CYP-Metabolisation or an error? —Preceding unsigned comment added by 88.68.176.11 (talk) 20:01, 14 November 2010 (UTC)

I agree: the extra methyl group on the pyridine looks very dodgy to me: it either needs to be commented on in the text and on the arrow (eg action of P450) or removed, but the source diagram has no attribution. 2001:630:206:FFFF:0:0:3128:A (talk) 17:07, 10 April 2013 (UTC)

Confirming from patent EP 1603537 A2 Figure 1 ( http://www.google.com/patents/EP1603537A2?cl=en ) the lack of additional methylation at the 6- position in vivo. The diagram needs to be fixed 81.141.92.246 (talk) 20:06, 10 April 2013 (UTC)

I have now fixed the image. -- Ed (Edgar181) 13:36, 15 April 2013 (UTC)

References

In the article it mentions that Omeprazole is available in countries over the counter, yet no references, or names of countries where this is the case are provided.62.31.151.148 (talk) 16:48, 31 May 2009 (UTC)

Ridiculous brand names

Should there really be like 100 brand names? I would assume the original brand name should be in the article, but not a gigantic list of every countrys' name for it. —Preceding unsigned comment added by 69.205.97.220 (talk) 07:13, 28 January 2009 (UTC)

Older entries

I removed the comment about Salmonella, because it doesn't usually infect the upper gastrointestinal tract does it? Also, PPIs don't completely stop gastric acid secretion. Techelf 11:55, 27 Jun 2004 (UTC)

I have a problem with the "it is falsely believed" part about allegations that AstraZeneca developed Nexium to mitigate the financial hit from Prilosec's going generic.

The article on esomeprazole (Nexium) reports a live controversy on the subject, linking a New Yorker article by Malcolm Gladwell.

So, anyone with more expertise -- should that language be altered to make it more neutral? --Andersonblog 21:42, 26 November 2006 (UTC)

I also have a problem with the "it is falsely believed" part. Although Nexium may consist only of the active enantiomers, I'm not sure that this is clinically significant. In other words, Nexium may be more potent an agent in decreasing acid production, but a patient taking Nexium will show no significant clinical difference from a patient taking Prilosec. Prilosec may not be as efficient, but it still gets the job done. —The preceding unsigned comment was added by 192.35.79.70 (talk • contribs) 07:38, 29 November 2006 (UTC).

Valpopa's edits leave a sentence fragment, in addition to providing no citation and not clearly relating to the preceeding text (at least as far as I am able to understand). Should they just be reverted? Ysth 23:20, 4 June 2007 (UTC)

Please, we all know that all drug company look for a way to slightly change the formula of a drug so that they can sell it for another 7 year as non generic! Wake up!!!! —Preceding unsigned comment added by 72.205.242.44 (talk) 15:07, 16 February 2008 (UTC)

Side effects

Does anyone know of any side effects? --204.49.34.2 12:41, 15 June 2007 (UTC)

Will add to the article. Fvasconcellos (t·c) 13:26, 15 June 2007 (UTC)

Added. Fvasconcellos (t·c) 01:36, 17 June 2007 (UTC)

Anaphylatic Reactions cited at: http://www.theannals.com/cgi/content/abstract/34/4/474 —Preceding unsigned comment added by 71.127.17.39 (talk) 05:31, 19 January 2009 (UTC)

This class of drugs has serious side effects that are only now being understood. In particular osteoperosis with just a few years of use, because it intereferes with calcium absorbtion. This is a very dangerous remedy for heartburn. There needs to be a more extensive entry on the side effects with recent research.

Bad grammar

"While it has been proven that only enantiomers in the "active" form are effective and others are not, due to the fact that the type of cytochrome which metabolizes the drug." There is no main clause in this sentence. Does the writer mean "It has been proven that only enantiomers in the "active" form are effective because of the type of cytochrome which metabolizes the drug"? If this does not alter the meaning it would be a more elegant way of expressing it. A.McMillan.

Calm down. --Haizum μολὼν λαβέ 23:24, 7 November 2007 (UTC)

If the original comment was too excited, I may need to adjust my own meds. This passage was improved by an edit from GngstrMNKY on 7 Oct 2007. MaxEnt 03:19, 14 November 2007 (UTC)

Noticed a minor spelling mistake, but am new to this so will allow someone else to fix it.'Other drugs that are depedent on CYP3A4 for their metabolism is Oxycodone Tramadol Oxymorphone etc.(Like most if not all Opioids) Wich also is metabolised via CYP2D6' Error is 'wich' and not 'which' - Mustard

Hangover

Would it be unethical to mention in this article how good this drug is at treating the common alcohol 'hangover'? One of these the night before and then another in the morning and I'm right as rain. 81.106.138.53 (talk) 22:10, 1 January 2008 (UTC)otto was here

Before Eating

The language on the packaging says to take "before eating." This could be taken two ways: take the pill on an empty stomach, and wait a while before eating, or alternatively: take the pill on an empty stomach and then eat something immediately thereafter. It sounds like to former is what is intended, but it would be good for a qualified pharmacologist to enhance the language in the "Absorption and distribution" section to be explicit. (140.232.0.70 (talk) 18:25, 23 November 2009 (UTC))

It should be taken on an empty stomach, with water. You should fast at least 60 minutes before taking omeprazole, and for another 30 minutes after taking it (60 minutes for Zegerid).

The current article says, "The capsule should be taken immediately before a meal. The MUPS tablet may be taken with or without food." That is contrary to most sources.

The current article cites MIMS, and the MIMS article does indeed say that. But that is contrary to the usual instructions given for taking omeprazole.

All sources agree that omeprazole should be taken with water on an empty stomach (i.e., at least 60 minutes after eating). Most sources also say that you should not eat immediately after taking omeprazole, and you should not take it with food (unless a little bit of applesauce is needed to help swallow it, for people who have trouble taking pills). Most sources say that after taking omeprazole you should not eat for at least 30 minutes for enteric-coated/delayed-release preparations (including MUPS tablets like Prilosec OTC)[1], or for at least 60 minutes for immediate-release plus sodium bicarbonate preparations (like Zegerid).[2].

I'm going to revise the article. NCdave (talk) 07:29, 11 November 2010 (UTC)

Interactions?

I have noticed that Omeprazole shares metabolic mechanisms with other drugs such as Clonazepam, and SSRIs like Escitalopram and Citalopram. In fact, these other pages make reference to the fact that using Omeprazole with these drugs can lead to heightened serum levels due to their shared hepatic clearance mechanisms. I think this information should be included in this article. Please include with a primary source. --1000Faces (talk) 16:18, 1 December 2009 (UTC)

Done. Don't forget that secondary sources are preferred over primary sources. Fvasconcellos (t·c) 18:53, 1 December 2009 (UTC)

scan of instructions provided with drug

http://img440.imageshack.us/img440/7695/scan033w.jpg —Preceding unsigned comment added by Muleattack (talk • contribs) 01:00, 10 October 2010 (UTC)

Constipation as a side effect?

Has anybody heard of constipation being a side effect for this drug?
Chocom (talk) 14:18, 17 January 2011 (UTC)

Look at the scan I provided above, it's a common side effect. Muleattack (talk) 16:56, 17 January 2011 (UTC)

This shouldn't belong in here, right?

In Bangladesh Apex Pharma Limited also marketed omeprazole under the brand name "Aspra" which is a very good medicine 190.212.31.1 (talk) 05:10, 15 June 2011 (UTC)

I removed the "which is a very good medicine" part. -- Ed (Edgar181) 11:07, 15 June 2011 (UTC)

Would this link be appropriate? http://www.acidrefluxsymptomsnow.com — Preceding unsigned comment added by TomLibelt (talk • contribs) 05:19, 10 December 2011 (UTC)

Which works better?

Which works better, omeprazole or zantac? — Preceding unsigned comment added by 67.58.92.76 (talk) 21:56, 6 June 2013 (UTC)

Interactions

Could someone more experienced than me edit the Interactions section for this medication? It has SERIOUS grammatical issues, but I don't want to change anything, because I'm not sure if the information is correct, either. Help! — Preceding unsigned comment added by 69.169.139.88 (talk) 17:53, 9 November 2013 (UTC)

More About Side Effects

Anecdotal - Lucky me! I ended up in the emergency room with severe abdominal pain, dehydration, uncontrollable nausea and retching after being prescribed with this med. Initially, I was simply uncomfortable and thought it was a stomach bug. But five weeks later and 15 pounds lighter I figured out that my problems began three days after taking this med. The package insert states that these side effects are more common in those who take the drug when compared with placebo. Two days after I stopped taking this med, my symptoms disappeared.

bpage (talk) 23:43, 29 March 2014 (UTC)

Warfarine and CYP3A4

It has been verified that Warfarine is metabolized partly or fully by the enzyme CYP3A4. Roshu Bangal (talk) 18:41, 23 August 2015 (UTC)

Structure Error

The structures on the right side of the "chemistry" sections have phenyl instead of pyrimidine groups — Preceding unsigned comment added by 66.243.219.231 (talk) 15:47, 12 September 2017 (UTC)

I have removed the image for now. I'll create a replacement shortly. -- Ed (Edgar181) 15:44, 17 July 2018 (UTC)

Another possible side effect = Microscopic Colitis.

"Microscopic Colitis Associated With Omeprazole and Esomeprazole Exposure"

Wilcox, Gilbert M. MD*; Mattia, Anthony R. MD†
Journal of Clinical Gastroenterology 43(6):p 551-553, July 2009. | DOI: 10.1097/MCG.0b013e31817d3fa1
https://journals.lww.com/jcge/Abstract/2009/07000/Microscopic_Colitis_Associated_With_Omeprazole_and.8.aspx

Thank you for your time, Wordreader (talk) 21:57, 17 June 2023 (UTC)