Taxifolin 8-monooxygenase

In enzymology, a taxifolin 8-monooxygenase (EC 1.14.13.19) is an enzyme that catalyzes the chemical reaction

taxifolin 8-monooxygenase
Identifiers
EC no.1.14.13.19
CAS no.39307-19-2
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MetaCycmetabolic pathway
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taxifolin + NAD(P)H + H+ + O2 2,3-dihydrogossypetin + NAD(P)+ + H2O

The 5 substrates of this enzyme are taxifolin, NADH, NADPH, H+, and O2, whereas its 4 products are 2,3-dihydrogossypetin, NAD+, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating). This enzyme is also called taxifolin hydroxylase. It has 2 cofactors: FAD, and Flavoprotein.

References

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  • Jeffrey AM, Knight M, Evans WC (1972). "The bacterial degradation of flavonoids. Hydroxylation of the A-ring of taxifolin by a soil pseudomonad". Biochem. J. 130 (2): 373–81. PMC 1174416. PMID 4146277.


  NODES
Note 1