1580 in science

	… 1570; 1571; 1572; 1573; 1574; 1575; 1576; ; 1577; 1578; 1579; 1580; 1581; 1582; 1583; ; 1584; 1585; 1586; 1587; 1588; 1589; 1590 …;
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The year 1580 in science and technology included many events, some of which are listed here.

Astronomy

September 26 – Francis Drake in the Golden Hind sails into Plymouth having completed the second circumnavigation of the world, westabout, begun in 1577.

Severe outbreak of smallpox in Venezuela: it strikes the Caracas and other Indians in the North and greatly weakens Indian resistance to the Spanish colonizing of the region.^[1]

January 12 – Jan Baptist van Helmont, Flemish chemist (died 1644)^[3]
December 1 – Nicolas-Claude Fabri de Peiresc, French astronomer (died 1637)
Peter Crüger, German polymath (died 1639)
Willebrord Snellius, Dutch mathematician and physicist who devised the basic law of refraction, Snell's law (died 1626)

^ George C. Kohn, Encyclopedia of plague and pestilence : From ancient times to the present, Infobase Publishing, 2007, p. 436.
^ Palmer, Alan; Palmer, Veronica (1992). The Chronology of British History. London: Century Ltd. pp. 160–162. ISBN 0-7126-5616-2.
^ "Jan Baptista van Helmont – Belgian scientist". Encyclopædia Britannica. Retrieved 3 April 2018.