CLEC4M

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene. CLEC4M has also been designated as CD299 (cluster of differentiation 299).

CLEC4M
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K9J, 1SL6, 1XAR, 1XPH, 3JQH
Identifiers
Aliases	CLEC4M, CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M
External IDs	OMIM: 605872; MGI: 2157942; HomoloGene: 129771; GeneCards: CLEC4M; OMA:CLEC4M - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 7,763,210 bp End 7,769,605 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A1.1 Start 3,793,397 bp End 3,798,984 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver germinal epithelium lymph node pancreatic ductal cell right lung testicle placenta left ovary right adrenal gland left adrenal cortex Top expressed in granulocyte lip skin of abdomen right kidney muscle of thigh spleen right lung lobe white adipose tissue carotid body skin of external ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide antigen binding virus receptor activity metal ion binding calcium-dependent protein binding mannose binding virion binding ICAM-3 receptor activity carbohydrate binding signaling receptor activity protein binding Cellular component cytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region host cell Biological process leukocyte cell-cell adhesion cell-cell recognition intracellular transport of virus intracellular signal transduction antigen processing and presentation endocytosis adaptive immune response immune system process viral genome replication peptide antigen transport modulation by virus of host process innate immune response viral process virion attachment to host cell viral entry into host cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10332 170786 Ensembl ENSG00000104938 ENSMUSG00000031494 UniProt Q9H2X3 Q91ZX1 RefSeq (mRNA) NM_001144904 NM_001144905 NM_001144906 NM_001144907 NM_001144908 NM_001144909 NM_001144910 NM_001144911 NM_014257 NM_214675 NM_214676 NM_133238 RefSeq (protein) NP_001138376 NP_001138377 NP_001138378 NP_001138379 NP_001138380 NP_001138381 NP_001138382 NP_001138383 NP_055072 NP_573501 Location (UCSC) Chr 19: 7.76 – 7.77 Mb Chr 8: 3.79 – 3.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Further reading

• Baribaud F, Doms RW, Pöhlmann S (2006). "The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?". Expert Opin. Ther. _targets. 6 (4): 423–31. doi:10.1517/14728222.6.4.423. PMID 12223058. S2CID 21541850.
• Becker Y (2004). "HIV-1 gp120 binding to dendritic cell receptors mobilize the virus to the lymph nodes, but the induced IL-4 synthesis by FcepsilonRI+ hematopoietic cells damages the adaptive immunity--a review, hypothesis, and implications". Virus Genes. 29 (1): 147–65. doi:10.1023/B:VIRU.0000032797.43537.d3. PMID 15215692. S2CID 5666009.
• Lalor PF, Lai WK, Curbishley SM, et al. (2006). "Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo". World J. Gastroenterol. 12 (34): 5429–39. doi:10.3748/wjg.v12.i34.5429. PMC 4088223. PMID 17006978.
• Curtis BM, Scharnowske S, Watson AJ (1992). "Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8356–60. Bibcode:1992PNAS...89.8356C. doi:10.1073/pnas.89.17.8356. PMC 49917. PMID 1518869.
• Gattegno L, Ramdani A, Jouault T, et al. (1992). "Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1)". AIDS Res. Hum. Retroviruses. 8 (1): 27–37. doi:10.1089/aid.1992.8.27. PMID 1736938.
• Soilleux EJ, Barten R, Trowsdale J (2000). "DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13". J. Immunol. 165 (6): 2937–42. doi:10.4049/jimmunol.165.6.2937. PMID 10975799.
• Pöhlmann S, Soilleux EJ, Baribaud F, et al. (2001). "DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2670–5. Bibcode:2001PNAS...98.2670P. doi:10.1073/pnas.051631398. PMC 30196. PMID 11226297.
• Bashirova AA, Geijtenbeek TB, van Duijnhoven GC, et al. (2001). "A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection". J. Exp. Med. 193 (6): 671–8. doi:10.1084/jem.193.6.671. PMC 2193415. PMID 11257134.
• Mummidi S, Catano G, Lam L, et al. (2001). "Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts". J. Biol. Chem. 276 (35): 33196–212. doi:10.1074/jbc.M009807200. PMID 11337487.
• Mitchell DA, Fadden AJ, Drickamer K (2001). "A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands". J. Biol. Chem. 276 (31): 28939–45. doi:10.1074/jbc.M104565200. PMID 11384997.
• Feinberg H, Mitchell DA, Drickamer K, Weis WI (2002). "Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR". Science. 294 (5549): 2163–6. doi:10.1126/science.1066371. PMID 11739956. S2CID 25046581.
• Alvarez CP, Lasala F, Carrillo J, et al. (2002). "C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans". J. Virol. 76 (13): 6841–4. doi:10.1128/JVI.76.13.6841-6844.2002. PMC 136246. PMID 12050398.
• Soilleux EJ, Morris LS, Rushbrook S, et al. (2002). "Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity". Hum. Pathol. 33 (6): 652–9. doi:10.1053/hupa.2002.124036. PMID 12152166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lin G, Simmons G, Pöhlmann S, et al. (2003). "Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR". J. Virol. 77 (2): 1337–46. doi:10.1128/JVI.77.2.1337-1346.2003. PMC 140807. PMID 12502850.
• Pöhlmann S, Zhang J, Baribaud F, et al. (2003). "Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR". J. Virol. 77 (7): 4070–80. doi:10.1128/JVI.77.7.4070-4080.2003. PMC 150620. PMID 12634366.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Engering A, van Vliet SJ, Hebeda K, et al. (2004). "Dynamic populations of dendritic cell-specific ICAM-3 grabbing nonintegrin-positive immature dendritic cells and liver/lymph node-specific ICAM-3 grabbing nonintegrin-positive endothelial cells in the outer zones of the paracortex of human lymph nodes". Am. J. Pathol. 164 (5): 1587–95. doi:10.1016/S0002-9440(10)63717-0. PMC 1615649. PMID 15111305.

External links

• CLEC4M+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• CLEC4M human gene location in the UCSC Genome Browser.
• CLEC4M human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.