Druce is a surname. Notable people with the surname include:
- Duncan Druce (1939–2015), British composer and musicologist
- Eliot Druce (1876–1934), English cricketer
- Frank Druce (1875–1954), English cricketer
- George Claridge Druce (1850–1932), British botanist
- Helen Margaret Druce (1921–2010), New Zealand teacher, tramper, botanist and botanical collector
- Herbert Druce (1846–1913), British entomologist
- Hamilton Herbert Druce (1869–1922), British entomologist, son of the above
- John Druce (born 1966), Canadian ice hockey player
- Joseph Druce (born 1965), American prisoner who murdered John Geoghan
- Olga Druce, American radio and television producer, public speaker, and actress
- Thomas W. Druce (born 1961), former member of the Pennsylvania House of Representatives, US
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