Geroprotector

A geroprotector aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals.^[1]^[2] Some possible geroprotectors include melatonin,^[3] carnosine,^[4] metformin,^[5] rapamycin,^[6] nicotinamide mononucleotide (NMN)^[7] and delta sleep-inducing peptide.^[8]

Geroprotectors could belong to multiple classes depending on which of the hallmarks of aging they influence.^{[citation needed]}

The distinction between geroprotectors and senotherapeutics is an evolving area of aging research. Geroprotectors broadly aim to _target multiple mechanisms of aging, prolonging lifespan and healthspan by addressing the fundamental causes of aging. Senotherapeutics, on the other hand, are a subset of therapies that specifically _target senescent cells, which are dysfunctional cells that accumulate with age and contribute to inflammation and age-related diseases.^[9]

References

^ Alexey Moskalev, Elizaveta Chernyagina, Anna Kudryavtseva & Mikhail Shaposhnikov (2017). "Geroprotectors: A Unified Concept and Screening Approaches". Aging and Disease. 8 (3): 354–363. doi:10.14336/AD.2016.1022. PMC 5440114. PMID 28580190.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Alexey Moskalev, Elizaveta Chernyagina, João Pedro de Magalhães & Alex Zhavoronkov (2015). "Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease". Aging. 7 (9): 616–628. doi:10.18632/aging.100799. PMC 4600621. PMID 26342919.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Anisimov, VN; Popovich, IG; Zabezhinski, MA; Anisimov, SV; Vesnushkin, GM; Vinogradova, IA (2006). "Melatonin as antioxidant, geroprotector and anticarcinogen". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1757 (5–6): 573–89. doi:10.1016/j.bbabio.2006.03.012. PMID 16678784.
^ Boldyrev, AA; Stvolinsky, SL; Fedorova, TN; Suslina, ZA (2010). "Carnosine as a natural antioxidant and geroprotector: From molecular mechanisms to clinical trials". Rejuvenation Research. 13 (2–3): 156–8. doi:10.1089/rej.2009.0923. PMID 20017611.
^ Bulterijs, S (2011). "Metformin As a Geroprotector". Rejuvenation Research. 14 (5): 469–82. doi:10.1089/rej.2011.1153. PMID 21882902. S2CID 40645408.
^ Dumas, Sabrina N; Lamming, Dudley W (2020-01-01). "Next Generation Strategies for Geroprotection via mTORC1 Inhibition". The Journals of Gerontology: Series A. 75 (1): 14–23. doi:10.1093/gerona/glz056. ISSN 1079-5006. PMC 6909887. PMID 30794726.
^ Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice, Cell Metabolism 24, 795–806, December 13, 2016 ª 2016 Elsevier Inc.
^ Bondarenko, TI (2011). "Mechanism of delta-sleep inducing peptide geroprotective activity". Adv Gerontol. 24 (1): 80–92. PMID 21809625.
^ Al-Naggar, Iman M. A. (24 October 2020). "Senolytics: _targeting Senescent Cells for Age-Associated Diseases". Current Molecular Biology Reports. 6: 161–172 – via Springer.

External links

Geroprotectors: Database of geroprotectors
For Youth: The Skin - Marine Collagen Peptides
Aging Chart Archived 2014-12-16 at the Wayback Machine: A collection of knowledge related to aging

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[1] Alexey Moskalev, Elizaveta Chernyagina, Anna Kudryavtseva & Mikhail Shaposhnikov (2017). "Geroprotectors: A Unified Concept and Screening Approaches". Aging and Disease. 8 (3): 354–363. doi:10.14336/AD.2016.1022. PMC 5440114. PMID 28580190.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[2] Alexey Moskalev, Elizaveta Chernyagina, João Pedro de Magalhães & Alex Zhavoronkov (2015). "Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease". Aging. 7 (9): 616–628. doi:10.18632/aging.100799. PMC 4600621. PMID 26342919.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[3] Anisimov, VN; Popovich, IG; Zabezhinski, MA; Anisimov, SV; Vesnushkin, GM; Vinogradova, IA (2006). "Melatonin as antioxidant, geroprotector and anticarcinogen". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1757 (5–6): 573–89. doi:10.1016/j.bbabio.2006.03.012. PMID 16678784.

[4] Boldyrev, AA; Stvolinsky, SL; Fedorova, TN; Suslina, ZA (2010). "Carnosine as a natural antioxidant and geroprotector: From molecular mechanisms to clinical trials". Rejuvenation Research. 13 (2–3): 156–8. doi:10.1089/rej.2009.0923. PMID 20017611.

[5] Bulterijs, S (2011). "Metformin As a Geroprotector". Rejuvenation Research. 14 (5): 469–82. doi:10.1089/rej.2011.1153. PMID 21882902. S2CID 40645408.

[6] Dumas, Sabrina N; Lamming, Dudley W (2020-01-01). "Next Generation Strategies for Geroprotection via mTORC1 Inhibition". The Journals of Gerontology: Series A. 75 (1): 14–23. doi:10.1093/gerona/glz056. ISSN 1079-5006. PMC 6909887. PMID 30794726.

[7] Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice, Cell Metabolism 24, 795–806, December 13, 2016 ª 2016 Elsevier Inc.

[8] Bondarenko, TI (2011). "Mechanism of delta-sleep inducing peptide geroprotective activity". Adv Gerontol. 24 (1): 80–92. PMID 21809625.

[9] Al-Naggar, Iman M. A. (24 October 2020). "Senolytics: _targeting Senescent Cells for Age-Associated Diseases". Current Molecular Biology Reports. 6: 161–172 – via Springer.

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Geroprotector

See also

References

External links