L&S may refer to:
- L&S, commonly known as Leedy & Strupe, a company formed after the purchase of the Leedy Manufacturing Company
- Laverne & Shirley, an American television situation comedy
- Lilo & Stitch, Disney franchise
- the Lehigh and Susquehanna Railroad, a defunct railroad in Pennsylvania
- A Latin Dictionary, often referred to as "Lewis and Short"
This disambiguation page lists articles associated with the title L&S.
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