Lanosterol
konposatu kimiko
Lanosterola esterolen saileko alkohola da (C28H44O). Mutur batean daukan hidroxilo taldeari esker molekula anfipatikoa da.
| Lanosterol | |
|---|---|
 | |
| Formula kimikoa | C30H50O |
| SMILES kanonikoa | 2D eredua |
| SMILES isomerikoa | C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)C |
| MolView | 3D eredua |
| Konposizioa | karbono |
| Mota | Esterol eta [[(3S,10S,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol|(3S,10S,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en)  |
| Estereoisomeroa | (+)-tirucallol (en) , [[(3S,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol|(3S,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en) , [[(3S,5R,10S,13S,14S,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol|(3S,5R,10S,13S,14S,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en) , [[(3R,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol|(3R,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en) , [[(3S,5S,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol|(3S,5S,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en) , [[(3R,5R,10S,13S,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol|(3R,5R,10S,13S,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2S)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol]] (en) eta Euphol (en) |
| Masa molekularra | 426,386 Da |
| Erabilera | |
| Rola | primary metabolite (en) |
| Identifikatzaileak | |
| InChlKey | CAHGCLMLTWQZNJ-BQNIITSRSA-N |
| CAS zenbakia | 79-63-0 |
| ChemSpider | 216175 |
| PubChem | 246983 |
| Reaxys | 2226449 |
| Gmelin | 16521 |
| ChEMBL | CHEMBL225111 |
| EC zenbakia | 201-214-9 |
| ECHA | 100.001.105 |
| CosIng | 34865 |
| MeSH | D007810 |
| RxNorm | 1442199 |
| Human Metabolome Database | HMDB0001251 |
| KNApSAcK | C00003657 |
| UNII | 1J05Z83K3M |
| KEGG | C01724 |
| PDB Ligand | LAN |
Biosintesia
aldatuEskualeno izeneko triterpenotik ekoizten da eta lanosterola oinarri hartuta eratzen dira gainerako esteroideak.
Osasuna
aldatuAzken ikerketek erakutsi dute ugaztunetan begi-lausoa edo "katarata" sortzea ekiditen duela[1].
Erreferentziak
aldatu- ↑ (Ingelesez) Zhang, Kang; Yan, Yong-Bin; Liu, Yizhi; Zhang, Liangfang; Wang, Jun; Sun, Xiaodong; Li, Yingrui; Granet, David et al.. (2015-07). «Lanosterol reverses protein aggregation in cataracts» Nature 523 (7562): 607–611. doi:. ISSN 1476-4687. (Noiz kontsultatua: 2018-12-30).
Kanpo estekak
aldatu
Datuak: Q414996
Multimedia: Lanosterol / Q414996