FOXP3

FOXP3 (forkhead box P3) est le marqueur des lymphocytes T régulateurs, codé par le gène FOXP3, situé sur le chromosome X humain. Il est un membre de la famille de protéines de type FOX. Ce gène code lui-même le répresseur de transcription Scurfin.

FOXP3
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 3QRF, 4WK8
Identifiants
Aliases	FOXP3
IDs externes	OMIM: 300292 MGI: 1891436 HomoloGene: 8516 GeneCards: FOXP3
Position du gène (Homme) Chr. Chromosome X Locus Xp11.23 Début 49,250,438 bp Fin 49,270,477 bp
Position du gène (Souris) Chr. X chromosome (souris) Locus X A1.1|X 3.41 cM Début 7,439,883 bp Fin 7,461,484 bp
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans gonade testicule tendon of biceps brachii ganglion lymphatique cæcum appendice iléo-cæcal sang tonsille vésicule biliaire granulocyte Fortement exprimé dans urètre male urethra blastocyste embryon pharynx thymus méninges tail of embryo dentate gyrus of hippocampal formation granule cell neural layer of retina Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire sequence-specific DNA binding NF-kappaB binding transcription corepressor activity Fixation d'acide nucléique transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding liaison protéique liaison d'histone déacétylase DNA-binding transcription factor activity NFAT protein binding liaison d'histone acétyltransférase liaison ion métal liaison ADN protein homodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Composant cellulaire noyau intracellulaire cytoplasme nucléoplasme complexe macromoléculaire Processus biologique negative regulation of cell population proliferation negative regulation of NF-kappaB transcription factor activity B cell homeostasis regulation of isotype switching to IgG isotypes myeloid cell homeostasis negative regulation of inflammatory response positive regulation of interleukin-4 production regulation of immunoglobulin production regulation of transcription by RNA polymerase II regulation of T cell anergy negative regulation of interleukin-6 production tolerance induction to self antigen regulation of transcription, DNA-templated negative regulation of DNA-binding transcription factor activity positive regulation of T cell tolerance induction negative regulation of immune response negative regulation of interferon-gamma production tolerance induction regulatory T cell differentiation régulation positive de la transcription dépendante de l'ADN negative regulation of interleukin-2 production positive regulation of histone acetylation negative regulation of interleukin-5 production negative regulation of chronic inflammatory response CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of activated T cell proliferation positive regulation of gene expression negative regulation of interleukin-4 production negative regulation of interleukin-10 production negative regulation of tumor necrosis factor production T cell homeostasis negative regulation of CREB transcription factor activity negative regulation of T-helper 17 cell differentiation T cell activation positive regulation of immature T cell proliferation in thymus positive regulation of regulatory T cell differentiation negative regulation of transcription by RNA polymerase II positive regulation of peripheral T cell tolerance induction positive regulation of transforming growth factor beta1 production negative regulation of transcription, DNA-templated negative regulation of lymphocyte proliferation negative regulation of histone acetylation negative regulation of interleukin-17 production response to virus negative regulation of histone deacetylation CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation negative regulation of T cell proliferation Remodelage de la chromatine cytokine production negative regulation of T cell cytokine production negative regulation of isotype switching to IgE isotypes T cell receptor signaling pathway positive regulation of T cell anergy transcription, DNA-templated T cell mediated immunity negative regulation of gene expression morphogenèse d'une structure anatomique regulation of Wnt signaling pathway regulation of regulatory T cell differentiation Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 50943 20371 Ensembl ENSG00000049768 ENSMUSG00000039521 UniProt Q9BZS1 Q99JB6 RefSeq (mRNA) NM_001114377 NM_014009 NM_001199347 NM_001199348 NM_054039 RefSeq (protéine) NP_001107849 NP_054728 NP_001186276 NP_001186277 NP_473380 Localisation (UCSC) Chr X: 49.25 – 49.27 Mb Chr X: 7.44 – 7.46 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

FoxP3 est essentiel pour l'acquisition de propriétés régulatrices par les lymphocytes TCD4+CD25+, on peut dire que FoxP3 est le "rhéostat de la réponse immunitaire".