Acuaporina 3

Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Nomenclatura	Outros nomes AQP3, AQP-3, GIL, acuaporina 3 (grupo sanguíneo GIL) ;
Símbolo	AQP3 (HGNC: 636)
Identificadores; externos	OMIM: 600170 ; MGI: 1333777 ; HomoloGene: 21025 ; EBI: AQP3; GeneCards: Xene AQP3; UniProt: AQP3;
Locus	Cr. 9 p13.3
Ontoloxía Xénica	Referencias: AmiGO / QuickGO
	Referencias: AmiGO / QuickGO
Ortólogos
Especies
Humano	Rato
Entrez
360	11828
Ensembl
Véxase HS	Véxase MM
UniProt
Q92482	Q8R2N1
RefSeq; (ARNm)
NM_004925	NM_016689
RefSeq; (proteína) NCBI
NP_001305073	NP_057898
Localización (UCSC)
Cr. 9:; 33.44 – 33.45 Mb	Cr. 4:; 41.09 – 41.1 Mb
PubMed (Busca)
360 ;	11828

A acuaporina 3 é unha proteína que funciona como canle acuosa que se encontra na membrana plasmática basolateral das células principais do conduto colector e proporciona unha vía para que a auga saia das células.^[1] No ril, a AQP3 é regulada pola vasopresina (ADH).^[2] Esta proteína é tamén un determinante para o sistema de grupos sanguíneos GIL.^[3] Nos humanos está codificada no xene AQP3 do cromosoma 9.

O ácido suberoilaniluro hidroxámico (SAHA) (un inhibidor de HDAC) incrementa a expresión de acuaporina 3 en células de pel normal (queratinocitos).^[4]

Importancia clínica

Os niveis de AQP3 adoitan ser máis baixos na psoríase que cando a pel está sa.^[4]

A AQP3 exprésase máis no eccema atópico.^[5]

Notas

↑ Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. PMID 9558461. doi:10.1146/annurev.physiol.60.1.199.
↑ Baynes JW, Dominiczak MH (2014). "Medical Biochemistry". Medical Biochemistry (Textbook) (4 ed.): 346 – vía Elsevier.
↑ Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. PMID 12239222. doi:10.1074/jbc.M208999200.
↑ ^4,0 ^4,1 Cancer therapy shows promise for psoriasis treatment
↑ Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema.". Allergy 61 (9): 1132–7. PMID 16918518. doi:10.1111/j.1398-9995.2006.01151.x.

Véxase tamén

Outros artigos

Acuaporina

Bibliografía

Bietz S, Montilla I, Külzer S, et al. (2009). "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte.". Mol. Biochem. Parasitol. 167 (1): 48–53. PMID 19393693. doi:10.1016/j.molbiopara.2009.04.006.
Bahamontes-Rosa N, Tena-Tomás C, Wolkow J, et al. (2008). "Genetic conservation of the GIL blood group determining aquaporin 3 gene in African and Caucasian populations.". Transfusion 48 (6): 1164–8. PMID 18435676. doi:10.1111/j.1537-2995.2008.01683.x.
Wang S, Amidi F, Beall M, et al. (2006). "Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture.". J. Soc. Gynecol. Investig. 13 (3): 181–5. PMID 16638588. doi:10.1016/j.jsgi.2006.02.002.
Ben Y, Chen J, Zhu R, et al. (2008). "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells.". Respiratory Physiology & Neurobiology 161 (2): 111–8. PMID 18280225. doi:10.1016/j.resp.2007.12.007.
Yasui H, Kubota M, Iguchi K, et al. (2008). "Membrane trafficking of aquaporin 3 induced by epinephrine.". Biochem. Biophys. Res. Commun. 373 (4): 613–7. PMID 18601899. doi:10.1016/j.bbrc.2008.06.086.
Horie I, Maeda M, Yokoyama S, et al. (2009). "Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes.". Biochem. Biophys. Res. Commun. 387 (3): 564–8. PMID 19619514. doi:10.1016/j.bbrc.2009.07.077.
Bellemère G, Von Stetten O, Oddos T (2008). "Retinoic acid increases aquaporin 3 expression in normal human skin.". J. Invest. Dermatol. 128 (3): 542–8. PMID 17943189. doi:10.1038/sj.jid.5701047.
Cohly HH, Isokpehi R, Rajnarayanan RV (2008). "Compartmentalization of aquaporins in the human intestine.". Int J Environ Res Public Health 5 (2): 115–9. PMC 2694936. PMID 18678926. doi:10.3390/ijerph5020115.
Lee TC, Ho IC, Lu WJ, Huang JD (2006). "Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line.". J. Biol. Chem. 281 (27): 18401–7. PMID 16672223. doi:10.1074/jbc.M601266200.
Hara-Chikuma M, Verkman AS (2008). "Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing.". J. Mol. Med. 86 (2): 221–31. PMID 17968524. doi:10.1007/s00109-007-0272-4.
Hara-Chikuma M, Takahashi K, Chikuma S, et al. (2009). "The expression of differentiation markers in aquaporin-3 deficient epidermis.". Arch. Dermatol. Res. 301 (3): 245–52. PMC 3582396. PMID 19184071. doi:10.1007/s00403-009-0927-9.
Wang J, Tanji N, Kikugawa T, et al. (2007). "Expression of aquaporin 3 in the human prostate.". Int. J. Urol. 14 (12): 1088–92; discussion 1092. PMID 18036046. doi:10.1111/j.1442-2042.2007.01901.x.
Higuchi S, Kubota M, Iguchi K, et al. (2007). "Transcriptional regulation of aquaporin 3 by insulin.". J. Cell. Biochem. 102 (4): 1051–8. PMID 17471492. doi:10.1002/jcb.21350.
Tancharoen S, Matsuyama T, Abeyama K, et al. (2008). "The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation.". J. Cell. Physiol. 217 (2): 338–49. PMID 18543247. doi:10.1002/jcp.21506.
Richardson SM, Knowles R, Marples D, et al. (2008). "Aquaporin expression in the human intervertebral disc.". J. Mol. Histol. 39 (3): 303–9. PMID 18247144. doi:10.1007/s10735-008-9166-1.
Avril-Delplanque A, Casal I, Castillon N, et al. (2005). "Aquaporin-3 expression in human fetal airway epithelial progenitor cells.". Stem Cells 23 (7): 992–1001. PMID 16043462. doi:10.1634/stemcells.2004-0197.
Kida H, Miyoshi T, Manabe K, et al. (2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.". J. Membr. Biol. 208 (1): 55–64. PMID 16596446. doi:10.1007/s00232-005-0819-7.
Liu YL, Matsuzaki T, Nakazawa T, et al. (2007). "Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues.". Hum. Pathol. 38 (1): 171–8. PMID 17056099. doi:10.1016/j.humpath.2006.07.015.

Ligazóns externas

Sistema de grupos sanguíneos GIL en BGMUT Blood Group Antigen Gene Mutation Database no NCBI, NIH
Localización no xenoma humano de AQP3 e páxina con detalles sobre o xene AQP3 no UCSC Genome Browser.

[pmid9558461-1] Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. PMID 9558461. doi:10.1146/annurev.physiol.60.1.199.

[pmid9824541-2] Baynes JW, Dominiczak MH (2014). "Medical Biochemistry". Medical Biochemistry (Textbook) (4 ed.): 346 – vía Elsevier.

[pmid12239222-3] Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. PMID 12239222. doi:10.1074/jbc.M208999200.

[MCG2017-4] 4,0 ^4,1 Cancer therapy shows promise for psoriasis treatment

[5] Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema.". Allergy 61 (9): 1132–7. PMID 16918518. doi:10.1111/j.1398-9995.2006.01151.x.

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