CD30

O CD30 (cluster de diferenciación 30), tamén coñecido como TNFRSF8, é unha proteína de membrana da superficie celular da familia do receptor do factor de necrose tumoral e un marcador de tumores, que se expresa en linfocitos T e B activados, pero non en ditas células en repouso, e está codificado nun xene do cromosoma 1 humano.

O TRAF2 e TRAF5 poden interaccionar con este receptor, e median a transdución de sinais que orixina a activación do NF-κB. É un regulador positivo da apoptose, e tamén limita o potencial proliferativo e do efector CD8 autorreactivo de células T e protexe ao corpo contra a autoinmunidade. Existen dúas variantes de transcrición de splicing alternativo deste xene que codifican distintas isoformas.^[1]

O CD30 está asociado co linfoma de células grandes anaplástico. Exprésase no carcinoma embrional pero non no seminoma e é así un marcador útil para distinguir entre estes tumores de células xerminais.^[2] O CD30 e o CD15 exprésanse tamén nas células de linfoma de Hodgkin clásico.^[3]

Interaccións

O CD30 interacciona con TRAF5,^[4] TRAF1,^[5] TRAF2^[4]^[5] e TRAF3.^[5]

Notas

↑ "Entrez Gene: TNFRSF8 tumor necrosis factor receptor superfamily, member 8".
↑ Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL (2005). "[Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]". Zhonghua Bing Li Xue Za Zhi (en Chinese) 34 (11): 711–5. PMID 16536313.
↑ Gorczyca W, Tsang P, Liu Z; et al. (2003). "CD30-positive T-cell lymphomas co-expressing CD15: an immunohistochemical analysis". Int. J. Oncol. 22 (2): 319–24. PMID 12527929.
↑ ^4,0 ^4,1 Aizawa, S; Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (1997). "Tumor necrosis factor receptor-associated factor (TRAF) and TRAF2 are involved in CD30-mediated NFkappaB activation". J. Biol. Chem. 272 (4): 2042–5. PMID 8999898. doi:10.1074/jbc.272.4.2042.
↑ ^5,0 ^5,1 ^5,2 Ansieau, S; Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss H J (1996). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14053–8. PMC 19493. PMID 8943059. doi:10.1073/pnas.93.24.14053.

Véxase tamén

Bibliografía

Schneider C, Hübinger G (2003). "Pleiotropic signal transduction mediated by human CD30: a member of the tumor necrosis factor receptor (TNFR) family". Leuk. Lymphoma 43 (7): 1355–66. PMID 12389614. doi:10.1080/10428190290033288.
Horie R, Higashihara M, Watanabe T (2003). "Hodgkin's lymphoma and CD30 signal transduction". Int. J. Hematol. 77 (1): 37–47. PMID 12568298. doi:10.1007/BF02982601.
Tarkowski M (2004). "Expression and a role of CD30 in regulation of T-cell activity". Curr. Opin. Hematol. 10 (4): 267–71. PMID 12799531. doi:10.1097/00062752-200307000-00003.
Granados S, Hwang ST (2004). "Roles for CD30 in the biology and treatment of CD30 lymphoproliferative diseases". J. Invest. Dermatol. 122 (6): 1345–7. PMID 15175022. doi:10.1111/j.0022-202X.2004.22616.x.
Dürkop H, Latza U, Hummel M; et al. (1992). "Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease". Cell 68 (3): 421–7. PMID 1310894. doi:10.1016/0092-8674(92)90180-K.
Fonatsch C, Latza U, Dürkop H; et al. (1992). "Assignment of the human CD30 (Ki-1) gene to 1p36". Genomics 14 (3): 825–6. PMID 1330892. doi:10.1016/S0888-7543(05)80203-4.
Josimovic-Alasevic O, Dürkop H, Schwarting R; et al. (1989). "Ki-1 (CD30) antigen is released by Ki-1-positive tumor cells in vitro and in vivo. I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by an enzyme-linked immunosorbent assay". Eur. J. Immunol. 19 (1): 157–62. PMID 2537734. doi:10.1002/eji.1830190125.
Stein H, Gerdes J, Schwab U; et al. (1983). "Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population". Int. J. Cancer 30 (4): 445–59. PMID 6754630. doi:10.1002/ijc.2910300411.
Jung W, Krueger S, Renner C; et al. (1995). "Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources". Mol. Immunol. 31 (17): 1329–34. PMID 7527901. doi:10.1016/0161-5890(94)90051-5.
Shiota M, Fujimoto J, Semba T; et al. (1994). "Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3". Oncogene 9 (6): 1567–74. PMID 8183550.
Lee SY, Park CG, Choi Y (1996). "T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors". J. Exp. Med. 183 (2): 669–74. PMC 2192463. PMID 8627180. doi:10.1084/jem.183.2.669.
Gedrich RW, Gilfillan MC, Duckett CS; et al. (1996). "CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins". J. Biol. Chem. 271 (22): 12852–8. PMID 8662842. doi:10.1074/jbc.271.22.12852.
Horie R, Ito K, Tatewaki M; et al. (1996). "A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages". Blood 88 (7): 2422–32. PMID 8839832.
Aizawa S, Nakano H, Ishida T; et al. (1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". J. Biol. Chem. 272 (4): 2042–5. PMID 8999898. doi:10.1074/jbc.272.4.2042.
Lee SY, Lee SY, Choi Y (1997). "TRAF-interacting Protein (TRIP): A Novel Component of the Tumor Necrosis Factor Receptor (TNFR)- and CD30-TRAF Signaling Complexes That Inhibits TRAF2-mediated NF-κB Activation". J. Exp. Med. 185 (7): 1275–85. PMC 2196258. PMID 9104814. doi:10.1084/jem.185.7.1275.
Boucher LM, Marengère LE, Lu Y; et al. (1997). "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily". Biochem. Biophys. Res. Commun. 233 (3): 592–600. PMID 9168896. doi:10.1006/bbrc.1997.6509.
Duckett CS, Thompson CB (1997). "CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival". Genes Dev. 11 (21): 2810–21. PMC 316646. PMID 9353251. doi:10.1101/gad.11.21.2810.
Mizushima S, Fujita M, Ishida T; et al. (1998). "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)". Gene 207 (2): 135–40. PMID 9511754. doi:10.1016/S0378-1119(97)00616-1.
Kurts C, Carbone FR, Krummel MF; et al. (1999). "Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells". Nature 398 (6725): 341–4. PMID 10192335. doi:10.1038/18692.

Ligazóns externas

MeshName - CD30+Antigens [1]

[entrez-1] "Entrez Gene: TNFRSF8 tumor necrosis factor receptor superfamily, member 8".

[2] Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL (2005). "[Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]". Zhonghua Bing Li Xue Za Zhi (en Chinese) 34 (11): 711–5. PMID 16536313.

[3] Gorczyca W, Tsang P, Liu Z; et al. (2003). "CD30-positive T-cell lymphomas co-expressing CD15: an immunohistochemical analysis". Int. J. Oncol. 22 (2): 319–24. PMID 12527929.

[pmid8999898-4] 4,0 ^4,1 Aizawa, S; Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (1997). "Tumor necrosis factor receptor-associated factor (TRAF) and TRAF2 are involved in CD30-mediated NFkappaB activation". J. Biol. Chem. 272 (4): 2042–5. PMID 8999898. doi:10.1074/jbc.272.4.2042.

[pmid8943059-5] 5,0 ^5,1 ^5,2 Ansieau, S; Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss H J (1996). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14053–8. PMC 19493. PMID 8943059. doi:10.1073/pnas.93.24.14053.

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