Enterovirus betacoxsackie
Enterovirus betacoxsackie, colloquialemente Coxsackievirus B (CVB), es un specie de virus responsabile de gastrointestinal disordines, ma alsi de rar complicationes como pericardites e myocardites.
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| Enterovirus betacoxsackie ICTV, 2023 | ||||||||||||||||
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Se distingue 6 serotypos (notate CVB1 ad CVB6).
Le CVB es un ambiente factor contribuente al diabete de typo 1.
Epidemiologia
modificarLe virus se transmitte fecooralmente. Plus de 95 % del population ha essite infectate per un serotypo de CVB, principalmente durante le juventute.
Physiopathologia
modificarIste virus intestinal pote infectar pancreatic β-cellulas que produce le insulina in langerhans insulettas. Iste acute infection conduce generalmente al destruction del β-cellulas sin effective immunitari reaction contra le virus. Illo reduce alsi le expression de HLA moleculas de classe I e pote propagar se, dissimulate in altere β-cellulas (chronic infection). Su persistentia in iste cellulas pote esser responsabile de un immunitari reaction, in personnas geneticamente predisponite, contra β-cellulas ipse. Iste autoimmun destruction de β-cellulas es la causa del diabete de typo 1.[1][2]
Un vaccino infantil contra le CVB es studiate pro contribuar al prevention del diabete 1.[1]
Virologia
modificarEs un virus de ARN de singulo filamento de senso positive non inveloppate del familia Picornaviridae. Su genoma contine circa 7'400 basepares.
Referentias
modificar- ↑ 1,0 1,1 https://www.sciencesetavenir.fr/sante/diabete/ce-virus-pourrait-etre-a-l-origine-du-diabete-de-type-1_178469
- ↑ Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S; nPOD-Virus Working Group; You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Flodstrom-Tullberg M, Mallone R. (2024-03-08). "Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses". Science Advances 10 (10): eadl1122. doi:. PMID 38446892.