PAIN

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Small molecule _targeting NaV1.7 via inhibition of CRMP2-Ubc9 interaction reduces pain-related outcomes in a rodent osteoarthritic model

Hestehave, Sara; Allen, Heather N.; Gomez, Kimberly; More

PAIN. 166(1):99-111, January 2025.

Descending facilitation from rostral ventromedial medulla mu opioid receptor-expressing neurons is necessary for maintenance of sensory and affective dimensions of chronic neuropathic pain

Dogrul, Bekir Nihat; Machado Kopruszinski, Caroline; Dolatyari Eslami, Mahdi; More

PAIN. 166(1):153-159, January 2025.

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Despite evidence of sex-related differences in pain perception and modulation in humans and non-human mammals, many pre-clinical studies still do not address sex as a variable. Even less study is devoted to human gender differences in pain, especially as the classification of gender identity becomes more complex and fluid.

Throughout 2024, IASP will examine what is known about sex and gender differences in pain perception and modulation and address sex-and gender-related disparities in both the research and treatment of pain.

Articles published in PAIN related to this year’s theme are marked with the Global Year logo and added to an article collection.​​
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