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The Non-selective Monovalent Cationic Channels TRPM4 and TRPM5

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Transient Receptor Potential Channels

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

Transient Receptor Potential (TRP) proteins are non-selective cationic channels with a consistent Ca2+-permeability, except for TRPM4 and TRPM5 that are not permeable to this ion. However, Ca2+ is a major regulator of their activity since both channels are activated by a rise in internal Ca2+. Thus TRPM4 and TRPM5 are responsible for most of the Ca2+-activated non-selective cationic currents (NSCCa) recorded in a large variety of tissues. Their activation induces cell-membrane depolarization that modifies the driving force for ions as well as activity of voltage gated channels and thereby strongly impacts cell physiology. In the last few years, the ubiquitously expressed TRPM4 channel has been implicated in insulin secretion, the immune response, constriction of cerebral arteries, the activity of inspiratory neurons and cardiac dysfunction. Conversely, TRPM5 whose expression is more restricted, has until now been mainly implicated in taste transduction.

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Abbreviations

AMPA-R:

α-amino-3-hydroxyl-5-methyl-4-isoxalone-propionate receptor

calcin.:

calcineurin

DAG:

diacylglycerol

ΔV:

membrane potential

ΔΨ:

driving force

ER:

endoplasmic reticulum

G:

G-protein

GPCR:

G-protein coupled receptor

IP3 :

inositol 1,4,5-triphosphate

IP3R:

IP3 receptor

KATP :

ATP-dependant potassium channel;

mGLU-R:

metabotropic-glutamate receptor

PIP2 :

phosphatidylinositol 4,5-biphosphate

PKC:

protein kinase C

PLC:

phospholipase C

RyR:

ryanodine receptor

SUR:

sulphonylurea receptor

TCR:

T-cell receptor

TRPC6:

transient receptor potential canonical 6

TRPM4:

transient receptor potential melastatin 4

TRPM5:

transient receptor potential melastatin 5

Tyr-K:

tyrosine kinase

VDCa:

voltage-dependant calcium channel

VDNa channel:

voltage-dependant sodium channel

VR:

vasopressin receptor

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Aknowledgments

We thank Simon Patrick for constructive comments on the manuscript. Christophe Simard is a recipient of a fellowship from the French Ministère de l’Enseignement et de la Recherche.

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Authors and Affiliations

  1. Groupe Cœur et Ischémie, EA 3212, Université de Caen, Sciences D, F-14032, Caen Cedex, France

    Romain Guinamard

  2. Groupe Cœur et Ischémie, EA 3212, Université de Caen, F-14032, Caen Cedex, France

    Laurent Sallé & Christophe Simard

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  1. Romain Guinamard
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  2. Laurent Sallé
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  3. Christophe Simard
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Correspondence to Romain Guinamard .

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Editors and Affiliations

  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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Guinamard, R., Sallé, L., Simard, C. (2011). The Non-selective Monovalent Cationic Channels TRPM4 and TRPM5. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_8

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