(Q21115334)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41143

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

G protein-coupled enkephalin receptor activity

Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41143&geneProductId=UniProtKB:P41143

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41143&geneProductId=UniProtKB:P41143

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41143&geneProductId=UniProtKB:P41143

neuropeptide binding

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41143&geneProductId=UniProtKB:P41143

1 reference

24 April 2018

G protein-coupled opioid receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

8 April 2019

Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

receptor serine/threonine kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

G protein-coupled enkephalin receptor activity

Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

peptide binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

cell component

cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

axon terminus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

integral component of membrane

vesicle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

intrinsic component of plasma membrane

1 reference

8 April 2019

Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

4 references

8 April 2019

8 April 2019

Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

integral component of plasma membrane

1 reference

16 July 2018

The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41143&geneProductId=UniProtKB:P41143

dendrite membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

membrane raft

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

neuron projection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41143&geneProductId=UniProtKB:P41143

1 reference

16 July 2018

integral component of synaptic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

spine apparatus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

neuronal dense core vesicle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

integral component of postsynaptic density membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

integral component of plasma membrane

regulation of calcium ion transport

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

regulation of sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

eating behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

adult locomotory behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

negative regulation of protein oligomerization

1 reference

8 April 2019

δ-Opioid receptor activation reduces α-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

cellular response to growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

cellular response to toxic substance

1 reference

8 April 2019

δ-Opioid receptor activation reduces α-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

negative regulation of gene expression

1 reference

8 April 2019

δ-Opioid receptor activation reduces α-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

positive regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

δ-Opioid receptor activation reduces α-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

regulation of mitochondrial membrane potential

1 reference

8 April 2019

δ-Opioid receptor activation reduces α-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

positive regulation of CREB transcription factor activity

IC

1 reference

8 April 2019

δ-Opioid receptor activation reduces α-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

G protein-coupled opioid receptor signaling pathway

IC

IMP

1 reference

16 July 2018

Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41143&geneProductId=UniProtKB:P41143

IMP

immune response

1 reference

8 April 2019

Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

cellular response to hypoxia

1 reference

8 April 2019

δ-Opioid receptor activation reduces α-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

1 reference

8 April 2019

chemical synaptic transmission

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41143&geneProductId=UniProtKB:P41143

1 reference

16 July 2018

sensory perception of pain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41143&geneProductId=UniProtKB:P41143

1 reference

16 July 2018

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

8 April 2019

8 April 2019

A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41143

1 reference

8 April 2019

G protein-coupled opioid receptor signaling pathway

physically interacts with

IMP

1 reference

8866

17 August 2016

1 reference

7082

17 August 2016

1 reference

1663

17 August 2016

1 reference

7221

17 August 2016

1 reference

1643

17 August 2016

1 reference

1607

17 August 2016

1 reference

1616

17 August 2016

1 reference

1617

17 August 2016

1 reference

1623

17 August 2016

1 reference

1624

17 August 2016

1 reference

1626

17 August 2016

1 reference

1605

17 August 2016

1 reference

1627

17 August 2016

1 reference

1606

17 August 2016

1 reference

1611

17 August 2016

1 reference

1628

17 August 2016

1 reference

1629

17 August 2016

1 reference

7471

17 August 2016

1 reference

7563

17 August 2016

1 reference

1638

17 August 2016

1 reference

1639

17 August 2016

1 reference

1640

17 August 2016

1 reference

1641

17 August 2016

1 reference

1633

English

17 August 2016

codeine

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL485

cebranopadol

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL2364605

ADL-5747

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL561339

ADL-5859

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL494480

AZD7268

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1946618

naltrexone hydrochloride

antagonist

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1201149

nalbuphine hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1201132

naloxone hydrochloride

antagonist

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1718

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41143

Identifiers

MeSH descriptor ID

D017465

subject named as

Receptors, Opioid, delta

0 references

MeSH tree code

D12.776.543.750.695.620.200

0 references

D12.776.543.750.720.600.610.200

0 references

D12.776.543.750.750.555.610.200

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023