(Q287958)

http://www.ebi.ac.uk/interpro/protein/P08588

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.3.11

hierarchical database ID heuristic

2 October 2019

based on heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

beta-adrenergic receptor activity

1 reference

8 April 2019

Structural and functional analysis of the B cell epitopes recognized by anti-receptor autoantibodies in patients with Chagas' disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

PDZ domain binding

1 reference

8 April 2019

beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

epinephrine binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

norepinephrine binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08588&geneProductId=UniProtKB:P08588

1 reference

24 April 2018

adrenergic receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08588&geneProductId=UniProtKB:P08588

1 reference

5 June 2018

protein binding

4 references

8 April 2019

Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

8 April 2019

Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

IntAct protein interaction database

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

8 April 2019

β1-adrenergic receptor antagonists signal via PDE4 translocation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

alpha-2A adrenergic receptor binding

1 reference

8 April 2019

Heterodimerization of alpha 2A- and beta 1-adrenergic receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

protein heterodimerization activity

1 reference

8 April 2019

Heterodimerization of alpha 2A- and beta 1-adrenergic receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

beta1-adrenergic receptor activity

A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

cell component

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

5 references

8 April 2019

8 April 2019

A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

8 April 2019

8 April 2019

Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

8 April 2019

beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

integral component of plasma membrane

1 reference

5 June 2018

A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08588&geneProductId=UniProtKB:P08588

Schaffer collateral - CA1 synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

integral component of postsynaptic density membrane

1 reference

1 January 2018

beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

biological process

fear response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

negative regulation of multicellular organism growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

cell-cell signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08588&geneProductId=UniProtKB:P08588

1 reference

5 June 2018

positive regulation of cAMP-mediated signaling

1 reference

1 January 2018

Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08588&geneProductId=UniProtKB:P08588

activation of adenylate cyclase activity

1 reference

8 April 2019

A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

diet induced thermogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

adenylate cyclase-activating adrenergic receptor signaling pathway

positive regulation of heart contraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

1 reference

8 April 2019

positive regulation of GTPase activity

1 reference

8 April 2019

Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

positive regulation of the force of heart contraction by epinephrine-norepinephrine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

heat generation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

brown fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

response to cold

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

temperature homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08588&geneProductId=UniProtKB:P08588

1 reference

5 June 2018

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

1 reference

8 April 2019

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

regulation of postsynaptic membrane potential

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

adenylate cyclase-activating adrenergic receptor signaling pathway

Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

8 April 2019

Heterodimerization of alpha 2A- and beta 1-adrenergic receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

positive regulation of cold-induced thermogenesis

β(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

ISS

8 April 2019

Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08588

physically interacts with

1 reference

7479

17 August 2016

1 reference

7455

17 August 2016

1 reference

7445

17 August 2016

1 reference

536

17 August 2016

1 reference

535

17 August 2016

1 reference

91

17 August 2016

1 reference

537

17 August 2016

1 reference

538

17 August 2016

1 reference

7107

17 August 2016

1 reference

548

17 August 2016

1 reference

549

17 August 2016

1 reference

550

17 August 2016

1 reference

551

17 August 2016

1 reference

552

17 August 2016

1 reference

7178

17 August 2016

1 reference

7207

17 August 2016

1 reference

8035

17 August 2016

1 reference

570

17 August 2016

1 reference

553

17 August 2016

1 reference

554

17 August 2016

1 reference

555

17 August 2016

1 reference

2561

17 August 2016

1 reference

7297

17 August 2016

1 reference

547

English

17 August 2016

epinephrine

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL679

dopamine

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL59

norepinephrine

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1437

(−)-ephedrine

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL211456

isoproterenol hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1711

betaxolol hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1691

acebutolol hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1200813

Bisoprolol fumarate

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1472989

carteolol hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1201002

dipivefrin hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1200833

DL-dobutamine hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1200418

esmolol hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1201115

levobunolol hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1201177

propafenone hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1201063

propranolol hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1671

sotalol hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1700

timolol maleate

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1200870

metipranolol hydrochloride

1 reference

14 August 2023

https://platform.open_targets.org/drug/CHEMBL1200947

Gene Atlas image

PBB GE ADRB1 208214 at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P08588

1 reference

GPCR, rhodopsin-like, 7TM

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08588

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

9 August 2016

Transporter Classification Database ID

English

9.A.14.3.11

2 references

Transporter Classification database

13 March 2020

Transporter Classification database