(Q415159)

Rosuvastatin (English)

(3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-yl-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid

3 October 2016

stereoisomer of

1 reference

based on heuristic

inferred from InChI

(E,3R,5R)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid

1 reference

based on heuristic

inferred from InChI

chemical formula

C₂₂H₂₈FN₃O₆S

1 reference

Rosuvastatin (English)

19 November 2016

canonical SMILES

CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C

1 reference

Rosuvastatin (English)

19 November 2016

isomeric SMILES

CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C

1 reference

Rosuvastatin (English)

19 November 2016

defined daily dose

10 milligram

route of administration

oral administration

1 reference

https://www.whocc.no/atc_ddd_index/?code=C10AA07

1 reference

14 February 2018

World Health Organisation international non-proprietary name

rosuvastatin (English)

1 reference

rosuvastatin (English)

medical condition treated

3 October 2016

lipedema

1 reference

2 October 2018

heart disease

1 reference

2 October 2018

arteriosclerosis

1 reference

2 October 2018

rare dyslipidemia

1 reference

Food and Drug Administration

2 October 2018

12 August 2003

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/413KH5ZJ73

http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021366s016lbl.pdf

familial hypercholesterolemia

start time

12 August 2003

approved by

Food and Drug Administration

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/413KH5ZJ73

http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021366s016lbl.pdf

lipid metabolism disorder

start time

12 August 2003

approved by

Food and Drug Administration

1 reference

Inxight: Drugs Database

2 November 2018

https://drugs.ncats.io/drug/413KH5ZJ73

http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021366s016lbl.pdf

significant drug interaction

(S)-(−)-colchicine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fenofibrate

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ciprofibrate

1 reference

A reference set of clinically relevant adverse drug-drug interactions

gemfibrozil

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(2R)-daptomycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

bezafibrate

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(S)-(−)-colchicine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fenofibrate

1 reference

A reference set of clinically relevant adverse drug-drug interactions

saquinavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

saquinavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ciprofibrate

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ritonavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ritonavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

rac-warfarin

increased international normalised ratio

1 reference

A reference set of clinically relevant adverse drug-drug interactions

rac-warfarin

retroperitoneal hemorrhage

1 reference

A reference set of clinically relevant adverse drug-drug interactions

gemfibrozil

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atazanavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atazanavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fosamprenavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fosamprenavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

lopinavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

lopinavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(2R)-daptomycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

cyclosporine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

bezafibrate

1 reference

A reference set of clinically relevant adverse drug-drug interactions

acenocoumarol

increased international normalised ratio

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ledipasvir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ledipasvir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

physically interacts with

3-hydroxy-3-methylglutaryl-CoA reductase

subject has role

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2954

Australian pregnancy category D

17 August 2016

pregnancy category

1 reference

imported from Wikimedia project

English Wikipedia

US pregnancy category X

1 reference

imported from Wikimedia project

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category B

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Rosuvastatin

5 August 2017

1 reference

5 March 2018

0 references

0 references

0 references

0 references

Rosuvastatin

0 references

Identifiers

InChI

InChI=1S/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17-/m1/s1

1 reference

Rosuvastatin (English)

19 November 2016

2 references

Rosuvastatin (English)

19 November 2016

ChEBI release 2020-09-01

CAS Registry Number

287714-41-4

2 references

rosuvastatin (English)

19 November 2016

https://commonchemistry.cas.org/detail?cas_rn=287714-41-4

10 April 2021

1 reference

rosuvastatin (English)

19 November 2016

2 references

Rosuvastatin (English)

19 November 2016

Reaxys registry number

9670765

1 reference

rosuvastatin (English)

3 October 2016

ChEBI ID

38545

mapping relation type

2 references

ROSUVASTATIN (English)

19 November 2016

International Chemical Identifier

InChI

InChI=1S/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17-/m1/s1

1 reference

ROSUVASTATIN (English)

19 November 2016

2 references

inferred from InChIKey

splash10-014l-0029800000-3c828e60429014535277

1 reference

MassBank accession ID

MSBNK-UPAO-UPA00013

0 references

SPLASH

0 references

HSDB ID

7317

1 reference

Hazardous Substances Data Bank

28 October 2019

Rosuvastatin (English)

10 May 2021

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

DSSTOX compound identifier

0 references

0 references

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.216.011

27 December 2018

ECHA Substance Infocard ID

7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid (English)

quotation

CAS no.: 287714-41-4 (English)

100.216.011

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.216.011

27 December 2018

7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid (English)

quotation

CAS no.: 287714-41-4 (English)

1 reference

World Health Organisation international non-proprietary name numeric ID

Rosuvastatin (English)

publication date

17 November 2015

8021

0 references

Guide to Pharmacology Ligand ID

2954

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2954

rosuvastatin (English)

19 November 2016

0 references

1 reference

rosuvastatin (English)

19 November 2016

DrugBank ID

DB01098

1 reference

Human Metabolome Database ID

HMDB0015230

2 references

based on heuristic

inferred from InChIKey

2 references

rosuvastatin (English)

19 November 2016

MedlinePlus drug identifier

a603033

0 references

PatientsLikeMe treatment ID

0 references

1 reference

rosuvastatin (English)

19 November 2016

0 references

1 reference

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

rosuvastatin (English)

3 October 2016

1 reference

6 April 2020

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

UMLS CUI

C0965129

1 reference

rosuvastatin (English)