(Q4822789)

Leucine-rich repeat domain superfamily

1 reference

Toll-like receptor 7

1 reference

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

Leucine-rich repeat, typical subtype, protein family

1 reference

Leucine-rich repeat, protein family

1 reference

BspA type Leucine rich repeat region, protein family

1 reference

transmembrane signaling receptor activity

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

double-stranded RNA binding

1 reference

8 April 2019

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

single-stranded RNA binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

27 March 2018

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

27 March 2018

single-stranded RNA binding

pattern recognition receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

cell component

Golgi membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

endosome

receptor complex

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

phagocytic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

lysosome

endoplasmic reticulum

plasma membrane

1 reference

27 March 2018

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

endolysosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

cytoplasm

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

endosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

biological process

I-kappaB phosphorylation

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

positive regulation of inflammatory response

IC

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

toll-like receptor 9 signaling pathway

IC

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

positive regulation of interleukin-8 production

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

defense response to virus

Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

27 March 2018

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

cellular response to mechanical stimulus

IEP

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

microglial cell activation

IEP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

positive regulation of interleukin-6 production

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

MyD88-dependent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

positive regulation of chemokine production

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYK1&geneProductId=UniProtKB:Q9NYK1

1 reference

27 March 2018

toll-like receptor 7 signaling pathway

3 references

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

1 reference

8 April 2019

positive regulation of NIK/NF-kappaB signaling

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

toll-like receptor signaling pathway

I-kappaB kinase/NF-kappaB signaling

3 references

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

defense response to virus

Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYK1

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5003

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5051

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7198

language of work or name

English

object of statement has role

17 August 2016

cpg-52852

agonist

1 reference

Open _targets Platform

14 August 2023

https://platform.open_targets.org/drug/CHEMBL549344

Gene Atlas image

PBB GE TLR7 220146 at fs.png
732 × 530; 11 KB

0 references

has part(s)

BspA type Leucine rich repeat region

1 reference

Toll/interleukin-1 receptor homology (TIR) domain

1 reference

cysteine-rich flanking region, C-terminal

1 reference

leucine-rich repeat, typical subtype

1 reference

Leucine-rich repeat

1 reference