I was selfish. So selfish -- And you paid the price. You did, I did, Aunt May did. I will never ever forgive myself for that. I will never ever forget I could've stopped it. It's all clear to me now, Uncle Ben. It's like I've been wearing a blindfold and earmuffs all my life -- And someone just ripped them off. I see the world clearly now -- And I see what my place is in it. You were right -- With power comes responsibility. Absolutely. For some reason I've been given great power. And with great power then must come great responsibility. I will never let you down again, Uncle Ben. 
Appearing in "Life Lessons"
Featured Characters:
- Spider-Man (Peter Parker) (Main story and flashback)
Supporting Characters:
- May Parker (Main story and flashback)
- Ben Parker (Only in flashback)(Death)
- John Stacy (First appearance)
- Mary Watson (First appearance)
Other Characters
- Martha Osborn (First appearance; dies)
- NYPD (First appearance)
Antagonists:
- Green Goblin (Norman Osborn) (First appearance as Green Goblin)
- Burglar (Main story and flashback)
Locations:
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- Osborn Mansion
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Synopsis for "Life Lessons"
Harry Osborn is woken up by his mother's screams while a fire is burning down Osborn Mansion. Harry can't help his mother, who presumably dies, but he does see a monster throwing some fireballs and then leaving the place.
Peter arrives home to learn that his uncle has been shot by a burglar. As Spider-Man, he chases the burglar down to an abandoned warehouse, where he learns to his dismay that this is the same criminal he could have stopped before when he had the chance. At last he understands what his uncle had been trying to tell him, that with great power comes responsibility.
Notes
- This issue is reprinted in Ultimate Spider-Man Vol. 1: Power and Responsibility.