Plymouth Rock was a landmark in Massachusetts. It was the location where British sailing ships landed in North America in 1620 to found a colony.
History and specifics
Amy Coverman's ancestors were among the original settlers who arrived at Plymouth. (TNG - Day of Honor novel: Ancient Blood)
While growing up in the 2240s decade, Christine Chapel wrongly thought the first United States settlement was Plymouth Rock, only learning later in school that the colony in Jamestown, Virginia had been founded earlier. (TOS reference: Official Cooking Manual)