Table 2.
(a) Enrichment analysis of transcriptome data. Gene Ontology (biological process): IPF vs. HCs. Relevant terms were excerpted. (b) Enrichment analysis of transcriptome data. Gene Ontology (molecular functions): IPF vs. HCs. Relevant terms were excerpted.
| (a) | ||
| Terms (Gene Ontology: biological process) with upregulated genes | p-value | DEGs |
| Synaptic vesicle cycle (GO:0099504) | 0.017 | RAB3A, STX1A |
| Adherens junction maintenance (GO:0034334) | 0.023 | FERMT2 |
| Regulation of wound healing, spreading of epidermal cells (GO:1903689) | 0.027 | FERMT2 |
| Positive regulation of integrin activation (GO:0033625) | 0.039 | FERMT2 |
| Terms (Gene Ontology: biological process) with downregulated genes | p-value | DEGs |
| Negative regulation of blood coagulation (GO:0030195) | 0.015 | PDGFB, PDGFA |
| Fatty acid elongation, monounsaturated fatty acid (GO:0034625) | 0.037 | ELOVL7 |
| Fatty acid elongation, polyunsaturated fatty acid (GO:0034626) | 0.037 | ELOVL7 |
| Fatty acid elongation, unsaturated fatty acid (GO:0019368) | 0.037 | ELOVL7 |
| (b) | ||
| Terms (Gene Ontology: molecular functions) with upregulated genes | p-value | DEGs |
| Type I Transforming Growth Factor Beta Receptor Binding (GO:0034713) | 0.035 | FERMT2 |