Table 6.
(a) Enrichment analysis of transcriptome data. Gene Ontology (biological process): before vs. after NTD administration. Relevant terms were excerpted. (b) Enrichment analysis of transcriptome data. Gene Ontology (molecular functions): before vs. after NTD administration. Relevant terms were excerpted.
| (a) | ||
| Terms (Gene Ontology: biological process) with upregulated genes | p-value | DEGs |
| Negative regulation of plasminogen activation (GO:0010757) | 0.0003 | SERPINE1, SERPINE2 |
| Negative regulation of blood coagulation (GO:0030195) | 0.008 | SERPINE1, SERPINE2 |
| Fatty acid elongation, monounsaturated fatty acid (GO:0034625) | 0.028 | ELOVL6 |
| Fatty acid elongation, polyunsaturated fatty acid (GO:0034626) | 0.028 | ELOVL6 |
| Fatty acid elongation, unsaturated fatty acid (GO:0019368) | 0.028 | ELOVL6 |
| Negative regulation of cell adhesion mediated by integrin (GO:0033629) | 0.041 | SERPINE1 |
| Terms (Gene Ontology: biological process) with downregulated genes | p-value | DEGs |
| Regulation of wound healing (GO:0061041) | 0.024 | KANK1, F2RL1 |
| (b) | ||
| Terms (Gene Ontology: molecular functions) with downregulated genes | p-value | DEGs |
| Ceramide 1-Phosphate Binding (GO:1902387) | 0.026 | PLA2G4A |
| Epinephrine Binding (GO:0051379) | 0.026 | RNLS |
| Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor (GO:0016641) | 0.036 | RNLS |
| Calcium-Independent Phospholipase A2 Activity (GO:0047499) | 0.036 | PLA2G4A |
| MHC Class II Receptor Activity (GO:0032395) | 0.045 | HLA-DOA |