Table 2. List of candidate genes showing expression changes in MDD and BPD.
| Fold change
|
|||||
|---|---|---|---|---|---|
| Gene name | Symbol | Alias | Cytoband | AnCg | DLPFC |
| Major depressive disorder | |||||
| Glial high-affinity glutamate transporter, Na+-dependent | SLC1A2 | GLT-1; EAAT2 | 11p13 | 0.80 | 0.71 |
| Glial high-affinity glutamate transporter, Na+-dependent | SLC1A3 | GLAST; EAAT1 | 5p13 | 0.85 | 0.65 |
| Glutamine synthetase | GLUL | GS | 1q31 | 0.73 | 0.78 |
| Glutamate receptor, ionotropic, AMPA 1 | GRIA1 | AMPA1; IGluR1 | 5q31.1 | 1.3 | |
| Glutamate receptor, ionotropic, AMPA 3 | GRIA3 | AMPA3; IGluR3 | Xq25 | 1.18 | |
| Glutamate receptor, ionotropic, kainate 1 | GRIK1 | GluR5; EAA3 | 21q22.11 | 1.21 | |
| Glutamate receptor, ionotropic, kainate 5 | GRIK5 | GluR-KA2; EAA2 | 19q13.2 | 1.14 | 1.21 |
| GABAA receptor, beta 3 | GABARB3 | GABAARβ3 | 15q11.2 | 1.21 | |
| GABAA receptor, delta | GABRD | GABAARδ | 1p36.3 | 1.19 | |
| GABAA receptor, gamma 2 | GABARG2 | GABAARγ2 | 5q3.1 | 1.22 | |
| Bipolar affective disorder | |||||
| Glutamate receptor, ionotropic | GRIA1 | AMPA1; IGluR1 | 5q31.1 | 1.21 | |
| Glutamate receptor, ionotropic | GRIA3 | AMPA3; IGluR3 | Xq25 | 1.21 | |
| Glutamate receptor, ionotropic, kainate 1 | GRIK1 | GluR5; EAA3 | 21q22.11 | 0.78 | |
| Glutamate receptor, metabotropic 3 | GRM3 | mGluR3 | 7q21.1 | 1.24 | 1.26 |
| GABAA receptor, alpha 5 | GABRA5 | GABAARα5 | 15q11.2 | 1.24 | 1.20 |
| GABAB receptor 1 | GABBR1 | GABABR1 | 6p21.31 | 1.22 | |
Each record indicates the gene name, symbol, common name, cytoband, and fold changes (FC) of expression in the AnCg and/or DLPFC. Expression values, meeting a significance threshold of P ≤ 0.05 and a fold change of ≥1.175 were considered increases, and those with a fold change of ≤0.85 were considered decreases.