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. 2002 Oct 1;21(19):5195–5205. doi: 10.1093/emboj/cdf506

graphic file with name cdf506f1.jpg

Fig. 1. Reduced radiosensitivity of Chk2–/– mice and Chk2–/– splenocytes in vivo. (A) Kaplan–Meier survival curve of age-matched 8–16-week-old Chk2+/+ (n = 23), Chk2+/– (n = 37) and Chk2–/– (n = 36) mice after exposure to 8 Gy of X-rays. Data are combined from two separate experiments. (B and C) Normal appearance of intestine in Chk2+/+ (B) and Chk2–/– (C) mice 1 day after IR. (D and E) Atrophy of white pulp of the spleen and reduction of splenocyte number in Chk2+/+ mice (D), but not in Chk2–/– mice (E), 8 days after exposure to IR.

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