Table 1.
Patient laboratory values before and during treatment with PKC412
| Initial Presentation | Pretreatment | Cycle 1 | Cycle 2 | Cycle 3/Relapse | |
|---|---|---|---|---|---|
| Date | Apr 2003 | Jun 2003 | Jun-Jul 2003 | Jul-Aug 2003 | Aug-Sep 2003 |
| Hematology | |||||
| WBCs/mm3* | 15.8 | 8.4 | 8.0 | 7.9 | 12.2 |
| Differential count, % | |||||
| Segmented neutrophils | 14 | 19 | 46 | 44 | 20 |
| Bands | 10 | 6 | 29 | 26 | 7 |
| Lymphocytes | 19 | 19 | 11 | 17 | 7 |
| Monocytes | 8 | 5 | 7 | 8 | 0 |
| Eosinophils | 0 | 2 | 0 | 1 | 0 |
| Basophils | 0 | 0 | 0 | 0 | 0 |
| Immature myeloids | 31 | 3 | 2 | 4 | 51 |
| Blasts | 5 | 0 | 0 | 0 | 8 |
| Mast cells | 11 | 46 | 5 | 0 | 2 |
| Nucleated red blood cells/100 WBCs | 7 | 47 | 4 | 4 | 0 |
| Hemoglobin, g/dL† | 9.8∥ | 8.5∥ | 8.7∥ | 7.5∥ | 9.5∥ |
| Hematocrit, % | 29.8∥ | 26.6∥ | 25.8∥ | 22.8∥ | 31.0∥ |
| Platelets/mm3‡ | 5000∥ | 7000∥ | 13 000∥ | 16 000∥ | 11 000∥ |
| Chemistry | |||||
| Albumin, g/dL† | 2.4 | 2.2 | 2.8 | 3.4 | 2.3 |
| Total bilirubin, mg/dL§ | 1.2 | 4.8 | 2.1 | 1.3 | 13.6 |
| Direct bilirubin, mg/dL§ | 0.5 | 2.8 | 1.1 | 0.7 | 7.5 |
| LDH, U/L | 552 | 769 | 239 | 227 | 595 |
| Mastocytosis-related findings | |||||
| Serum histamine, ng/dL | ND | 6910 | 1031 | 779 | 2525 |
| Serum tryptase, μg/L | > 200 | > 200 | > 200 | > 200 | > 200 |
WBCs indicates white blood cells; LDH, lactate dehydrogenase.
*
To convert to × 109 cells per liter, multiply by 1.
†
To convert to grams per liter, multiply by 10.
‡
To convert to × 109 platelets per liter, divide by 1000.
§
To convert to micromoles per liter, multiply by 17.1.
∥
Transfusion-dependent.