TABLE 4.
Phenotype and hepatic gene expression in mice fed the control or CD diets for 14 days
Values are expressed as mean ± S.D. n = 6 for all parameters except plasma homocysteine for which n = 3 pooled samples with 2 mice per sample.
| Control | CD | |
|---|---|---|
| Plasma homocysteine (μm) | 13.6 ± 1.6 | 75.9 ± 26.1a |
| Body weight (g) | 21.0 ± 0.4 | 21.3 ± 1.0 |
| Change in body weight (%) | +1.6 ± 1.6 | +2.6 ± 4.4 |
| Plasma ALT (IU/L) | 35 ± 7 | 33 ± 5 |
| Plasma glucose (mg/dL) | 143 ± 32 | 175 ± 22 |
| Liver weight (g) | 1.00 ± 0.09 | 1.00 ± 0.03 |
| Liver wt/body wt (%) | 4.4 ± 0.2 | 4.7 ± 0.2 |
| Hepatic triglyceride (mg/mg protein) | 0.22 ± 0.06 | 0.36 ± 0.10a |
| Hepatic SAM (nmol/g liver) | 66.8 ± 13.0 | 55.3 ± 9.0 |
| Hepatic SAH (nmol/g liver) | 55.3 ± 14.8 | 71.8 ± 15.6 |
| SAM/SAH ratio | 1.3 ± 0.4 | 0.8 ± 0.3 |
| Relative mRNA levels | ||
| BiP | 1.3 ± 1.0 | 1.7 ± 0.8 |
| XBP-1(s) | 1.4 ± 1.3 | 1.4 ± 0.8 |
a p < 0.05 versus Control.