Figure 3. Deployment of branching modes.
a, Lungs from Fig. 1a with branches pseudocolored blue (domain branching), green (planar bifurcation), or red (orthogonal bifurcation) to indicate branching mode used to form the branch. b, Close-up of L.L2 (dorsal view, lateral at right) pseudocolored as in a. Lineage diagrams are also colored to indicate branching mode. Branching mode can switch between generations and a single branch (e.g. L.L2) can form daughters by more than one mode. Bar, 100 μm. c, Sequences of branching mode use. DB, domain branching; OB, orthogonal bifurcation; PB, planar bifurcation. Sequence 2 includes a lineage formed by Sequence 1 (dotted box) and Sequence 3 includes a lineage formed by Sequence 2 (dotted box). d, Diagram showing sequence in c used to generate each lineage (named after the founder branch, see Supplementary Fig. 1) off the lobar branches (R.Cr, R.Md, R.Ac, RCd, L). Most or all lineages within a domain use the same sequence.