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. Author manuscript; available in PMC: 2011 Nov 24.
Published in final edited form as: Chem Biol. 2010 Nov 24;17(11):1256–1266. doi: 10.1016/j.chembiol.2010.08.013

Figure 3.

Figure 3

Cardiovascular effects of AM3506 in anaesthetized SHR are mediated by CB1 receptors. Solid arrows indicate the i.v. injection to SHR (A) and WKY (B) of vehicle (○), 1 mg/kg AM3506 (●) and 1 mg/kg AM3506 following i.p. injection of 3 mg/kg AM251 60 min earlier (■). Open arrows indicate the i.v. injection of 3 mg/kg AM251 (▲) or 3 mg/kg AM6545 (◆) to a separate group of SHR, at the peak hypotensive response to AM3506. Values of MAP and HR are means±s.e.m. from 4–8 experiments.

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