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Quizartinib inhibits cellular proliferation of KIT-, FLT3- or PDGFR-dependent leukemia cells. Dilution series of quizartinib for several cell lines harboring mutant-FLT3, ABL1 or PDGFRA (1A) or mutant-KIT isoforms (1B) were performed and cellular proliferation was assessed using an XTT-based assay. Sensitivity towards quizartinib varied widely between the tested cell lines. IC50s and mutation isoforms for all tested cell lines are listed in Table 1.
