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. 2013 Aug 27;23(10):1163–1171. doi: 10.1038/cr.2013.122

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Copyright © 2013 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0

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Genome-wide expression analysis of cells transfected with the CRISPR-on system. (A) The histogram showing distribution of Log₂ fold changes of gene expression in sample transfected with dCas9VP160/sgTetO over dCas9VP160/sgTetO-mut control. (B) A histogram showing distribution of log₂ fold changes of gene expression in cells transfected with dCas9VP160/sgIL1RN1∼3 over dCas9VP160/sgTetO-mut control. Vertical line marks the fold change of the _target gene IL1RN. (C) Column graph showing the Log₂ fold changes of genes upregulated by at least 2-fold in cells transfected with dCas9VP160/sgTetO over dCas9VP160/sgTetO-mut. (D) Column graph showing the Log₂ fold changes of genes upregulated by more than 2-fold in cells transfected with dCas9VP160/sgIL1RN1∼3 over dCas9VP160/sgTetO-mut. Dotted line indicates the 2-fold cut-off.

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