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(A) Exercise increases in cardiac output (ΔCO) were impaired in heart failure with preserved ejection fraction (HFpEF; boxes–dashed line) compared with controls (circles–solid line) for any change in pulmonary capillary wedge pressure (ΔPCWP) or (B) LV end-diastolic volume. *Data available only for cohort 1 (n = 71 HFpEF and 25 controls); †Data available only for cohorts 2 and 3 (n = 38 HFpEF and 48 controls).
