FIGURE 8.
Icosabutate reduces atherosclerotic plaque formation in APOE*3Leiden.CETP mice. Representative images of the aortic root (A). (B) Total cholesterol exposure. (C) Total lesion area per cross section of the aortic root. (D) Number of lesions per cross section. (E) Percentage of undiseased aortic root segments and pathohistological scoring of lesions expressed as percentage of total number of lesions. Severity was classified as type I‐II: initial lesion/fatty streak, type III: intermediate lesion, type IV‐V: (fibro)atheroma lesion. Data are presented as mean ± SEM, *P ≤ .05, **P ≤ .01, ***P ≤ .001