Volume 128(2); 2023 Jan 19

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The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care

Maria Antonietta Cerone, Tara C. Mills, Rowena Sharpe, David McBride, Moira MacDonald, Suzanne MacMahon, Hood Mugalaasi, Pauline Rehal, Alessandro Rettino, Helen Roberts, Mark Ross, Donald Edward White, John Peden, Janette Rawlinson, Steffan N. Ho, Simon Hollingsworth, Sanjay Popat, Gary Middleton, Peter Johnson, Charles Swanton, the SMP2 consortium

Br J Cancer. 2023 Jan 19; 128(2): 161–164. Published online 2023 Jan 4. doi: 10.1038/s41416-022-02107-8

Correction in:: Br J Cancer. 2023 Jan 19; 128(2): 399.

PMCID:: PMC9902467

Abstract Article PDF–380K

Thinking inside the box: intracellular roles for complement system proteins come into focus

Rebecca M. O’Brien, Niamh Lynam-Lennon, Monica M. Olcina

Br J Cancer. 2023 Jan 19; 128(2): 165–167. Published online 2023 Jan 17. doi: 10.1038/s41416-022-02116-7

PMCID:: PMC9902547

Abstract Article PDF–460K

Review Articles

Association between angiotensin-converting enzyme inhibitors and the risk of lung cancer: a systematic review and meta-analysis

Zhenchao Wu, Taikang Yao, Zilu Wang, Beibei Liu, Nan Wu, Ming Lu, Ning Shen

Br J Cancer. 2023 Jan 19; 128(2): 168–176. Published online 2022 Nov 17. doi: 10.1038/s41416-022-02029-5

PMCID:: PMC9670057

Abstract Article PDF–580K

Prostate cancer in transgender women: considerations for screening, diagnosis and management

Fionnuala Crowley, Meredith Mihalopoulos, Simita Gaglani, Ashutosh K. Tewari, Che-Kai Tsao, Miroslav Djordjevic, Natasha Kyprianou, Rajveer S. Purohit, Dara J. Lundon

Br J Cancer. 2023 Jan 19; 128(2): 177–189. Published online 2022 Oct 19. doi: 10.1038/s41416-022-01989-y

PMCID:: PMC9902518

Abstract Article PDF–918K

Ferroptosis in hepatocellular carcinoma: mechanisms and _targeted therapy

Amir Ajoolabady, Daolin Tang, Guido Kroemer, Jun Ren

Br J Cancer. 2023 Jan 19; 128(2): 190–205. Published online 2022 Oct 13. doi: 10.1038/s41416-022-01998-x

PMCID:: PMC9902568

Abstract Article PDF–2.6M

The application of single-cell sequencing in pancreatic neoplasm: analysis, diagnosis and treatment

Gaoyuan Lv, Liang Zhang, Lei Gao, Jitao Cui, Ziying Liu, Bei Sun, Gang Wang, Qiushi Tang

Br J Cancer. 2023 Jan 19; 128(2): 206–218. Published online 2022 Oct 28. doi: 10.1038/s41416-022-02023-x

PMCID:: PMC9902442

Abstract Article PDF–1.0M

Articles

Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil

Bingxue Yang, Xinran Xie, Dazhao Lv, Jiajun Hu, Yuyun Chen, Zhaoyu Wu, Shuyue Luo, Shiyi Zhang

Br J Cancer. 2023 Jan 19; 128(2): 219–231. Published online 2022 Nov 8. doi: 10.1038/s41416-022-02039-3

PMCID:: PMC9902485

Abstract Article PDF–5.1M

Downregulation of CBX7 induced by EZH2 upregulates FGFR3 expression to reduce sensitivity to cisplatin in bladder cancer

Jiannan Ren, Haixin Yu, Wei Li, Xin Jin, Bin Yan

Br J Cancer. 2023 Jan 19; 128(2): 232–244. Published online 2022 Nov 17. doi: 10.1038/s41416-022-02058-0

PMCID:: PMC9902481

Abstract Article PDF–3.9M

PANTHER: AZD8931, inhibitor of EGFR, ERBB2 and ERBB3 signalling, combined with FOLFIRI: a Phase I/II study to determine the importance of schedule and activity in colorectal cancer

David J. Propper, Fangfei Gao, Mark P. Saunders, Debashis Sarker, John A. Hartley, Victoria J. Spanswick, Helen L. Lowe, Louise D. Hackett, Tony T. Ng, Paul R. Barber, Gregory E. Weitsman, Sarah Pearce, Laura White, Andre Lopes, Sharon Forsyth, Daniel Hochhauser

Br J Cancer. 2023 Jan 19; 128(2): 245–254. Published online 2022 Nov 9. doi: 10.1038/s41416-022-02015-x

PMCID:: PMC9902557

Abstract Article PDF–953K

Efficacy and safety of rucaparib treatment in patients with BRCA-mutated, relapsed ovarian cancer: final results from Study 10

Rebecca S. Kristeleit, Yvette Drew, Amit M. Oza, Susan M. Domchek, Susana Banerjee, Rosalind M. Glasspool, Judith Balmaña, Lee-may Chen, Manish R. Patel, Howard A. Burris, Tamar Safra, Jennifer Borrow, Kevin K. Lin, Sandra Goble, Lara Maloney, Ronnie Shapira-Frommer

Br J Cancer. 2023 Jan 19; 128(2): 255–265. Published online 2022 Dec 8. doi: 10.1038/s41416-022-02022-y

PMCID:: PMC9902459

Abstract Article PDF–553K

Incorporating weekly carboplatin in anthracycline and paclitaxel-containing neoadjuvant chemotherapy for triple-negative breast cancer: propensity-score matching analysis and TIL evaluation

Maria Vittoria Dieci, Luisa Carbognin, Federica Miglietta, Fabio Canino, Carlo Alberto Giorgi, Enrico Cumerlato, Ottavia Amato, Davide Massa, Gaia Griguolo, Elisa Genovesi, Giovanna Garufi, Diana Giannarelli, Antonio Tornincasa, Lucia Trudu, Silvia Michieletto, Tania Saibene, Marcello Lo Mele, Matteo Fassan, Giovanni Zarrilli, Federico Piacentini, Emilio Bria, Valentina Guarneri

Br J Cancer. 2023 Jan 19; 128(2): 266–274. Published online 2022 Nov 17. doi: 10.1038/s41416-022-02050-8

Correction in:: Br J Cancer. 2023 Jan 19; 128(2): 398.

PMCID:: PMC9902542

Abstract Article PDF–893K

Associations between serum glucose, insulin, insulin resistance and the risk of incident primary liver cancer or chronic liver disease mortality: a nested case–control study

Jian Yin, Neal D. Freedman, Yiwei Liu, Sanford M. Dawsey, Huan Yang, Philip R. Taylor, Liangyu Yin, Bin Liu, Jianfeng Cui, Jinhu Fan, Wen Chen, Youlin Qiao, Christian C. Abnet

Br J Cancer. 2023 Jan 19; 128(2): 275–284. Published online 2022 Dec 10. doi: 10.1038/s41416-022-02042-8

PMCID:: PMC9902537

Abstract Article PDF–367K

Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer

Michèle Rouleau, Flora Nguyen Van Long, Véronique Turcotte, Patrick Caron, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Lévesque, Chantal Guillemette

Br J Cancer. 2023 Jan 19; 128(2): 285–296. Published online 2022 Nov 8. doi: 10.1038/s41416-022-02040-w

PMCID:: PMC9902621

Abstract Article PDF–1.0M

The utility of ctDNA in detecting minimal residual disease following curative surgery in colorectal cancer: a systematic review and meta-analysis

Lucy G. Faulkner, Lynne M. Howells, Coral Pepper, Jacqueline A. Shaw, Anne L. Thomas

Br J Cancer. 2023 Jan 19; 128(2): 297–309. Published online 2022 Nov 8. doi: 10.1038/s41416-022-02017-9

PMCID:: PMC9902552

Abstract Article PDF–709K

The tumour-associated stroma correlates with poor clinical outcomes and immunoevasive contexture in patients with upper tract urothelial carcinoma: results from a multicenter real-world study (TSU-01 Study)

Longhao Xu, Wenlong Zhong, Chenchen Li, Peng Hong, Kun Xia, Rongcheng Lin, Sida Cheng, Bo Wang, Meng Yang, Junyu Chen, Lulin Ma, Xuesong Li, Liqun Zhou, Jian Huang, Tianxin Lin

Br J Cancer. 2023 Jan 19; 128(2): 310–320. Published online 2022 Nov 17. doi: 10.1038/s41416-022-02049-1

PMCID:: PMC9902452

Abstract Article PDF–1.0M

Clinical significance and functional role of adhesion G-protein-coupled receptors in human pancreatic ductal adenocarcinoma

Satoshi Nishiwada, Tadanobu Shimura, Kensuke Yamamura, Kenji Nakagawa, Minako Nagai, Kota Nakamura, Taichi Terai, Suguru Yamada, Tsutomu Fujii, Yasuhiro Kodera, Masayuki Sho, Ajay Goel

Br J Cancer. 2023 Jan 19; 128(2): 321–330. Published online 2022 Nov 17. doi: 10.1038/s41416-022-02057-1

PMCID:: PMC9902480

Abstract Article PDF–694K

CXCR1/2 dual-inhibitor ladarixin reduces tumour burden and promotes immunotherapy response in pancreatic cancer

Geny Piro, Carmine Carbone, Antonio Agostini, Annachiara Esposito, Maria De Pizzol, Rubina Novelli, Marcello Allegretti, Andrea Aramini, Alessia Caggiano, Alessia Granitto, Francesco De Sanctis, Stefano Ugel, Vincenzo Corbo, Maurizio Martini, Rita Teresa Lawlor, Aldo Scarpa, Giampaolo Tortora

Br J Cancer. 2023 Jan 19; 128(2): 331–341. Published online 2022 Nov 16. doi: 10.1038/s41416-022-02028-6

PMCID:: PMC9902528

Abstract Article PDF–3.0M

Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes

Heather J. Bax, Jitesh Chauhan, Chara Stavraka, Aida Santaolalla, Gabriel Osborn, Atousa Khiabany, Melanie Grandits, Jacobo López-Abente, Lais C. G. F. Palhares, Charleen Chan Wah Hak, Alexandra Robinson, Amy Pope, Natalie Woodman, Cristina Naceur-Lombardelli, Sadek Malas, Jack E. M. Coumbe, Mano Nakamura, Roman Laddach, Silvia Mele, Silvia Crescioli, Anna M. Black, Sara Lombardi, Silvana Canevari, Mariangela Figini, Ahmad Sayasneh, Sophia Tsoka, Kevin FitzGerald, Cheryl Gillett, Sarah Pinder, Mieke Van Hemelrijck, Rebecca Kristeleit, Sharmistha Ghosh, Ana Montes, James Spicer, Sophia N. Karagiannis, Debra H. Josephs

Br J Cancer. 2023 Jan 19; 128(2): 342–353. Published online 2022 Nov 19. doi: 10.1038/s41416-022-02031-x

PMCID:: PMC9902484

Abstract Article PDF–2.2M

Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension

Leni van Doorn, Wesley J. Visser, Daan C. H. van Dorst, Katrina M. Mirabito Colafella, Stijn L. W. Koolen, Anneke van Egmond- de Mik, Ingrid M. Garrelds, Dominique M. Bovée, Esther Oomen- de Hoop, Sander Bins, Ferry A. L. M. Eskens, Ewout J. Hoorn, A. H. Jan Danser, Ron H. J. Mathijssen, Jorie Versmissen

Br J Cancer. 2023 Jan 19; 128(2): 354–362. Published online 2022 Nov 10. doi: 10.1038/s41416-022-02036-6

PMCID:: PMC9647750

Abstract Article PDF–505K

Metformin abrogates Fusobacterium nucleatum-induced chemoresistance in colorectal cancer by inhibiting miR-361-5p/sonic hedgehog signaling-regulated stemness

Xia-Lu Hong, Ta-Chung Yu, Xiao-Wen Huang, Ji-Lin Wang, Tian-Tian Sun, Ting-Ting Yan, Cheng-Bei Zhou, Hui-Min Chen, Wen-Yu Su, Wan Du, Hua Xiong

Br J Cancer. 2023 Jan 19; 128(2): 363–374. Published online 2022 Nov 17. doi: 10.1038/s41416-022-02044-6

PMCID:: PMC9902563

Abstract Article PDF–2.4M

Intratumoral heterogeneity affects tumor regression and Ki67 proliferation index in perioperatively treated gastric carcinoma

Magnus Kock am Brink, Laura Sophie Dunst, Hans-Michael Behrens, Sandra Krüger, Thomas Becker, Christoph Röcken

Br J Cancer. 2023 Jan 19; 128(2): 375–386. Published online 2022 Nov 8. doi: 10.1038/s41416-022-02047-3

PMCID:: PMC9902476

Abstract Article PDF–1.7M

Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils

Damian Jacenik, Ioannis Karagiannidis, Ellen J. Beswick

Br J Cancer. 2023 Jan 19; 128(2): 387–397. Published online 2022 Nov 14. doi: 10.1038/s41416-022-02056-2

PMCID:: PMC9902541

Abstract Article PDF–2.9M

Corrections

Correction: Incorporating weekly carboplatin in anthracycline and paclitaxel-containing neoadjuvant chemotherapy for triple-negative breast cancer: propensity-score matching analysis and TIL evaluation

Br J Cancer. 2023 Jan 19; 128(2): 398. Published online 2022 Dec 2. doi: 10.1038/s41416-022-02087-9

Corrects:: Br J Cancer. 2023 Jan 19; 128(2): 266–274.

PMCID:: PMC9902395

Correction PDF–245K

Correction to: The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care

Br J Cancer. 2023 Jan 19; 128(2): 399. Published online 2023 Jan 25. doi: 10.1038/s41416-023-02160-x

Corrects:: Br J Cancer. 2023 Jan 19; 128(2): 161–164.

PMCID:: PMC9902544

Correction PDF–271K

Correction to: A Phase 1B open-label study of gedatolisib (PF-05212384) in combination with other anti-tumour agents for patients with advanced solid tumours and triple-negative breast cancer

Giuseppe Curigliano, Geoffrey I. Shapiro, Rebecca S. Kristeleit, Albiruni R. Abdul Razak, Stephen Leong, Maria Alsina, Antonio Giordano, Karen A. Gelmon, Erica Stringer-Reasor, Ulka N. Vaishampayan, Mark Middleton, Anthony J. Olszanski, Hope S. Rugo, Kenneth A. Kern, Nuzhat Pathan, Rachelle Perea, Kristen J. Pierce, Sarah C. Mutka, Zev A. Wainberg

Br J Cancer. 2023 Jan 19; 128(2): 400. Published online 2023 Jan 25. doi: 10.1038/s41416-023-02161-w

Corrects:: Br J Cancer. 2023 Jan 26; 128(1): 30–41.

PMCID:: PMC9902525

Correction PDF–308K

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK