Volume 45(12); 2024 Dec

Articles from this journal are generally available in PMC after a 12-month delay (embargo); however, the delay may vary at the discretion of the publisher.

Articles

Ginsenoside Rg1 mitigates cerebral ischaemia/reperfusion injury in mice by inhibiting autophagy through activation of mTOR signalling

Zhi-chao Xi, Han-gui Ren, Lin Ai, Yuan Wang, Meng-fan Liu, Yu-fei Qiu, Ji-ling Feng, Wang Fu, Qian-qian Bi, Feng Wang, Hong-xi Xu

Acta Pharmacol Sin. 2024 Dec; 45(12): 2474–2486. Published online 2024 Jun 27. doi: 10.1038/s41401-024-01334-4

PMCID:: PMC11579309

Abstract Article PDF–6.4MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

Carotid artery transplantation of brain endothelial cells enhances neuroprotection and neurorepair in ischaemic stroke rats

Yi-ting Du, Zhi-guang Pan, Bin-chi Chen, Feng-yan Sun

Acta Pharmacol Sin. 2024 Dec; 45(12): 2487–2496. Published online 2024 Jul 11. doi: 10.1038/s41401-024-01339-z

PMCID:: PMC11579341

Abstract Article PDF–4.4MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer’s disease mouse model

Xian-hua Deng, Xing-yang Liu, Yi-hua Wei, Ke Wang, Jun-rong Zhu, Jia-jun Zhong, Jing-yuan Zheng, Rui Guo, Yi-fan Zhu, Qiu-hong Ye, Meng-dan Wang, Ying-jie Chen, Jian-quan He, Ze-xu Chen, Shu-qiong Huang, Chong-shan Lv, Guo-qing Zheng, Sui-feng Liu, Lei Wen

Acta Pharmacol Sin. 2024 Dec; 45(12): 2497–2512. Published online 2024 Jul 9. doi: 10.1038/s41401-024-01332-6

PMCID:: PMC11579518

Abstract Article PDF–6.9MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation

Xian-xi Ye, Qiao-ying Jiang, Meng-jun Wu, Qing-huai Ye, Hong Zheng

Acta Pharmacol Sin. 2024 Dec; 45(12): 2513–2526. Published online 2024 Jul 11. doi: 10.1038/s41401-024-01340-6

PMCID:: PMC11579283

Abstract Article PDF–6.7MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation

Ying Yang, Na Suo, Shi-hao Cui, Xuan Wu, Xin-yue Ren, Yin Liu, Ren Guo, Xin Xie

Acta Pharmacol Sin. 2024 Dec; 45(12): 2527–2539. Published online 2024 Jun 13. doi: 10.1038/s41401-024-01313-9

PMCID:: PMC11579360

Abstract Article PDF–8.1MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury

Cong-ting Guo, Blake D. Jardin, Jun-sen Lin, Rachelle L. Ambroise, Ze Wang, Lu-zi Yang, Neil Mazumdar, Fu-jian Lu, Qing Ma, Yang-po Cao, Can-zhao Liu, Kai-long Li, Xu-jie Liu, Feng Lan, Ming-ming Zhao, Han Xiao, Er-dan Dong, William T. Pu, Yu-xuan Guo

Acta Pharmacol Sin. 2024 Dec; 45(12): 2540–2552. Published online 2024 Jul 23. doi: 10.1038/s41401-024-01348-y

PMCID:: PMC11579379

Abstract Article PDF–4.6MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

DLK1 promoted ischemic angiogenesis through notch1 signaling in endothelial progenitor cells

Ya-yu You, Ning Zhang, Zhuo Wang, Zhe-hui Yin, Qin-yi Bao, Shu-xin Lei, Xiao-jie Xie

Acta Pharmacol Sin. 2024 Dec; 45(12): 2553–2566. Published online 2024 Jul 26. doi: 10.1038/s41401-024-01346-0

PMCID:: PMC11579026

Abstract Article PDF–11MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway

Yan-lu Han, Teng-teng Yan, Hua-xin Li, Sha-sha Chen, Zhen-zhen Zhang, Meng-yao Wang, Mei-jie Chen, Yuan-li Chen, Xiao-xiao Yang, Ling-ling Wei, Ya-jun Duan, Shuang Zhang

Acta Pharmacol Sin. 2024 Dec; 45(12): 2567–2578. Published online 2024 Jul 26. doi: 10.1038/s41401-024-01341-5

PMCID:: PMC11579491

Abstract Article PDF–8.5MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization

Xia-fang Lin, Xiao-na Cui, Jin Yang, Ya-fei Jiang, Tian-jiao Wei, Li Xia, Xin-yue Liao, Fei Li, Dan-dan Wang, Jian Li, Qi Wu, De-shan Yin, Yun-yi Le, Kun Yang, Rui Wei, Tian-pei Hong

Acta Pharmacol Sin. 2024 Dec; 45(12): 2579–2597. Published online 2024 Sep 18. doi: 10.1038/s41401-024-01389-3

PMCID:: PMC11579449

Abstract Article PDF–9.4M

Chromodomain Y‐like (CDYL) inhibition ameliorates acute kidney injury in mice by regulating tubular pyroptosis

Ting Xiang, Ling-zhi Li, Jin-xi Li, Xin-yun Chen, Fan Guo, Jing Liu, Yi-ting Wu, Lin Lin, Rui-han Xu, Hui-ping Wang, Liang Ma, Ping Fu

Acta Pharmacol Sin. 2024 Dec; 45(12): 2598–2610. Published online 2024 Jul 23. doi: 10.1038/s41401-024-01345-1

PMCID:: PMC11579507

Abstract Article PDF–6.3MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

G protein-coupled receptor kinase 2 as a novel therapeutic _target for gland fibrosis of Sjögren’s syndrome

Ru-hong Fang, Zheng-wei Zhou, Rui Chu, Qiu-yun Guan, Feng He, Ming-li Ge, Pai-pai Guo, Hua-xun Wu, Ling-li Yao, Wei Wei, Yang Ma, Qing-tong Wang

Acta Pharmacol Sin. 2024 Dec; 45(12): 2611–2624. Published online 2024 Jul 25. doi: 10.1038/s41401-024-01350-4

PMCID:: PMC11579508

Abstract Article PDF–8.9MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growth

Xue Wang, Qian-qian Li, Yan-xin Tang, Ye Li, Lu Zhang, Fei-fei Xu, Xue-li Fu, Kai Ye, Jia-qi Ma, Shi-man Guo, Fang-yuan Ma, Zhi-yu Liu, Xu-he Shi, Xian-meng Li, Hui-min Sun, Yue Wu, Wei-ying Zhang, Li-hong Ye

Acta Pharmacol Sin. 2024 Dec; 45(12): 2625–2645. Published online 2024 Jun 28. doi: 10.1038/s41401-024-01310-y

PMCID:: PMC11579023

Abstract Article PDF–9.7MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

Recombinant human adenovirus type 5 promotes anti-tumor immunity via inducing pyroptosis in tumor endothelial cells

Zhi-ming Wang, Meng-kai Li, Qing-ling Yang, Shi-xin Duan, Xin-yi Lou, Xin-yi Yang, Ying Liu, Yu-wen Zhong, Yu Qiao, Zi-shu Wang, Lei Sun, Feng Qian

Acta Pharmacol Sin. 2024 Dec; 45(12): 2646–2656. Published online 2024 Jul 19. doi: 10.1038/s41401-024-01349-x

PMCID:: PMC11579340

Abstract Article PDF–4.2MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

Adaptor protein CEMIP reduces the chemosensitivity of small cell lung cancer via activation of an SRC-YAP oncogenic module

Xiao-ju Shen, Hui-lan Wei, Xiao-cheng Mo, Xiao-xiang Mo, Li Li, Jing-chuan He, Xin-yu Wei, Xiao-jun Qin, Shang-ping Xing, Zhuo Luo, Zhi-quan Chen, Jie Yang

Acta Pharmacol Sin. 2024 Dec; 45(12): 2657–2671. Published online 2024 Jul 23. doi: 10.1038/s41401-024-01342-4

PMCID:: PMC11579373

Abstract Article PDF–7.8MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

Isotoosendanin inhibits triple-negative breast cancer metastasis by reducing mitochondrial fission and lamellipodia formation regulated by the Smad2/3-GOT2-MYH9 signaling axis

Jing-nan Zhang, Ze Zhang, Zhen-lin Huang, Qian Guo, Ze-qi Wu, Chuang Ke, Bin Lu, Zheng-tao Wang, Li-li Ji

Acta Pharmacol Sin. 2024 Dec; 45(12): 2672–2683. Published online 2024 Jul 15. doi: 10.1038/s41401-024-01335-3

PMCID:: PMC11579498

Abstract Article PDF–5.7MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

Review Article

Immunocyte membrane-derived biomimetic nano-drug delivery system: a pioneering platform for tumour immunotherapy

Yuan-ye Zeng, Qing Gu, Dan Li, Ai-xue Li, Rong-mei Liu, Jian-ying Liang, Ji-yong Liu

Acta Pharmacol Sin. 2024 Dec; 45(12): 2455–2473. Published online 2024 Jul 31. doi: 10.1038/s41401-024-01355-z

PMCID:: PMC11579519

Abstract Article PDF–5.1MCurrently embargoed: Free in PMC on Dec 1, 2025; PubMed

Correction

Publisher Correction: E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

Chun-yan Duan, Yue Li, Hao-yu Zhi, Yao Tian, Zheng-yun Huang, Su-ping Chen, Yang Zhang, Qing Liu, Liang Zhou, Xiao-gang Jiang, Kifayat Ullah, Qing Guo, Zhao-hui Liu, Ying Xu, Jun-hai Han, Jiajie Hou, Darran P O’Connor, Guoqiang Xu

Acta Pharmacol Sin. 2024 Dec; 45(12): 2684. Published online 2024 Jun 20. doi: 10.1038/s41401-024-01328-2

Corrects:: Acta Pharmacol Sin. 2024 Sep; 45(9): 1793–1808.

PMCID:: PMC11579322

Correction PDF–202K

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