American Journal of Psychiatry

Posttraumatic stress disorder (PTSD) is a highly prevalent psychiatric disorder that can become chronic and debilitating when left untreated. The most commonly recommended first-line treatments for PTSD among adults are individual trauma-focused ...

https://doi.org/10.1176/appi.ajp.20230950

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An Honest Reckoning With the Amygdala and Mental Illness

Publication date: 21 November 2024

Pages1059–1075

Anxiety disorders are a leading source of human misery, morbidity, and premature mortality. Existing treatments are far from curative for many, underscoring the need to clarify the underlying neural mechanisms. Although many brain regions contribute, the ...

https://doi.org/10.1176/appi.ajp.20240941

Articles

Resting-State Functional Connectivity of the Amygdala in Autism: A Preregistered Large-Scale Study

Publication date: 29 August 2024

Pages1076–1085

Objective: Three leading neurobiological hypotheses about autism spectrum disorder (ASD) propose underconnectivity between brain regions, atypical function of the amygdala, and generally higher variability between individuals with ASD than between ...

https://doi.org/10.1176/appi.ajp.20230249

Translational Insights From Cell Type Variation Across Amygdala Subnuclei in Rhesus Monkeys and Humans

Publication date: 30 October 2024

Pages1086–1102

Objective: Theories of amygdala function are central to our understanding of psychiatric and neurodevelopmental disorders. However, limited knowledge of the molecular and cellular composition of the amygdala impedes translational research aimed at ...

https://doi.org/10.1176/appi.ajp.20230602

Pathways to Homelessness: Childhood Maltreatment and Psychiatric Symptoms Increase Risk of Homelessness

Publication date: 21 November 2024

Pages1103–1111

Objective: Homelessness is a serious and increasing public health concern. Childhood maltreatment and psychiatric problems have been associated with homelessness as risk factors; however, reliance on cross-sectional studies introduces ambiguity into ...

https://doi.org/10.1176/appi.ajp.20230649

Discrimination Exposure, Neural Reactivity to Stress, and Psychological Distress

Publication date: 30 October 2024

Pages1112–1126

Objective: Discrimination exposure has a detrimental impact on mental health, increasing the risk of depression, anxiety, and posttraumatic stress. The impact discrimination exposure has on mental health is likely mediated by neural processes associated ...

https://doi.org/10.1176/appi.ajp.20220884