Review
doi: 10.1097/00041433-199904000-00003.
Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies
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- PMID: 10327277
- DOI: 10.1097/00041433-199904000-00003
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Review
Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies
Curr Opin Lipidol.
1999 Apr.
Abstract
The macrophage expresses a variety of genes that may contribute to lipoprotein metabolism and atherosclerotic lesion formation. Bone marrow transplantation experiments using gene-_targeted mice, both as donors and recipients, provide a useful approach to examine the contribution of macrophage gene expression to lipoprotein metabolism and atherogenesis in vivo. This article describes recent insights into the role of macrophage expression of apolipoprotein E and the LDL receptor gained from bone marrow transplantation studies in the mouse.
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