Review
doi: 10.1016/S0955-0674(99)80045-3.
Activation of RNA polymerase II transcription
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- PMID: 10395559
- DOI: 10.1016/S0955-0674(99)80045-3
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Review
Activation of RNA polymerase II transcription
Curr Opin Cell Biol.
1999 Jun.
Abstract
Multiple alternative interactions between activators and co-activators stimulate transcription by RNA polymerase II. In the past two years, multiprotein co-activator complexes have been characterized and their subunits defined. TATA-box binding protein associated factor (TAF) subunits of yeast TFIID were found to be generally required for transcription in vivo. Mammalian multisubunit coactivator complexes with homologs of the yeast SRB/Mediator subunits have been characterized. Structures of nuclear receptor-coactivator complexes have been determined.
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