Review
doi: 10.1016/s0968-0004(99)01503-0.
GHKL, an emergent ATPase/kinase superfamily
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- PMID: 10637609
- DOI: 10.1016/s0968-0004(99)01503-0
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Review
GHKL, an emergent ATPase/kinase superfamily
Trends Biochem Sci.
2000 Jan.
Abstract
An interesting recent development is the recognition of a novel ATP-binding superfamily that includes diverse protein families such as DNA topoisomerase II, molecular chaperones Hsp90, DNA-mismatch-repair enzymes MutL and histidine kinases. The most singular unifying feature of this superfamily is the unconventional Bergerat ATP-binding fold. The far-reaching significance of this commonality is still in the process of being explored.
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