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Review
. 2000:102:157-63.

Membrane filtration for virus removal

H Brandwein  1 , H Aranha-Creado
Affiliations
  • PMID: 10794103
Review

Membrane filtration for virus removal

H Brandwein et al. Dev Biol (Basel). 2000.

Abstract

Incorporation of adequate clearance methodologies for viral safety assurance constitutes an integral part of the manufacturing process for plasma-derived biologicals. Filtration, being non-invasive, non-destructive and a <<robust>> mechanism for virus removal is often the method of choice. This paper discusses the virus filter performance characteristics and other process-related issues specifically applying to the Pall Ultipor VF filters (Grade DV50 and Grade DV20), which are operated in the direct flow filtration (DFF) mode and the Pall Filtron Omega VR filters (the Omega 300 K and Omega 100 K), which are operated in the tangential flow filtration (TFF) mode.

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