Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
- PMID: 10875265
- DOI: 10.1210/endo.141.7.7586
Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
Abstract
GH has many biological roles, including promotion of growth. Most, if not all, of its roles are achieved through interaction with its receptor. We chose to study the effects of loss of GH signaling on growth and aging in a mouse model for Laron Syndrome (LS) in which the GHR/BP gene has been disrupted. We observed that mice homozygous for the disruption (-/-) were significantly smaller than normal wild-type (+/+) mice as well as mice heterozygous for the disruption, even at 1.5 yr of age. IGF-I levels were also significantly lower in the -/- mice and remained low as the mice aged. IGFBP-3 levels were severely reduced in the -/- mice, whereas IGFBP-1, -2, and -4 levels remained unchanged. Finally, the -/- mice lived significantly longer than +/+ and +/- mice. The latter result contradicts the anti-aging GH data and suggests the need for further analysis of GH and aging.
Similar articles
-
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.Endocrinology. 2003 Sep;144(9):3799-810. doi: 10.1210/en.2003-0374. Endocrinology. 2003. PMID: 12933651
-
A mammalian model for Laron syndrome produced by _targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse).Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13215-20. doi: 10.1073/pnas.94.24.13215. Proc Natl Acad Sci U S A. 1997. PMID: 9371826 Free PMC article.
-
The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: supression of GH secretion by GnRH analogue therapy not restored by dihydrotestosterone administration.Clin Endocrinol (Oxf). 2004 Jan;60(1):36-40. doi: 10.1111/j.1365-2265.2004.01930.x. Clin Endocrinol (Oxf). 2004. PMID: 14678285
-
Life extension in the dwarf mouse.Curr Top Dev Biol. 2004;63:189-225. doi: 10.1016/S0070-2153(04)63006-7. Curr Top Dev Biol. 2004. PMID: 15536017 Review.
-
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.Endocr Rev. 2011 Jun;32(3):356-86. doi: 10.1210/er.2010-0009. Epub 2010 Dec 1. Endocr Rev. 2011. PMID: 21123740 Free PMC article. Review.
Cited by
-
Growth hormone and aging.J Am Aging Assoc. 2000 Oct;23(4):219-25. doi: 10.1007/s11357-000-0021-x. J Am Aging Assoc. 2000. PMID: 23604867 Free PMC article.
-
Fat tissue and long life.Obes Facts. 2008;1(4):176-82. doi: 10.1159/000145930. Epub 2008 Aug 14. Obes Facts. 2008. PMID: 20054178 Free PMC article. Review.
-
Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice.FASEB J. 2010 Dec;24(12):5073-9. doi: 10.1096/fj.10-163253. Epub 2010 Aug 18. FASEB J. 2010. PMID: 20720157 Free PMC article.
-
ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective.Front Endocrinol (Lausanne). 2019 Feb 1;10:27. doi: 10.3389/fendo.2019.00027. eCollection 2019. Front Endocrinol (Lausanne). 2019. PMID: 30774624 Free PMC article. Review.
-
MicroRNA 132-3p Is Upregulated in Laron Syndrome Patients and Controls Longevity Gene Expression.Int J Mol Sci. 2021 Nov 1;22(21):11861. doi: 10.3390/ijms222111861. Int J Mol Sci. 2021. PMID: 34769292 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
