Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
- PMID: 11086983
- DOI: 10.1016/s0896-6273(00)00085-4
Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
Abstract
Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and control subjects and hierarchical data analysis revealed that transcripts encoding proteins involved in the regulation of presynaptic function (PSYN) were decreased in all subjects with schizophrenia. Genes of the PSYN group showed a different combination of decreased expression across subjects. Over 250 other gene groups did not show altered expression. Selected PSYN microarray observations were verified by in situ hybridization. Two of the most consistently changed transcripts in the PSYN functional gene group, N-ethylmaleimide sensitive factor and synapsin II, were decreased in ten of ten and nine of ten subjects with schizophrenia, respectively. The combined data suggest that subjects with schizophrenia share a common abnormality in presynaptic function. We set forth a predictive, testable model.
Similar articles
-
A quantitative study on the expression of synapsin II and N-ethylmaleimide-sensitive fusion protein in schizophrenic patients.Neurosci Lett. 2001 Jun 15;305(3):185-8. doi: 10.1016/s0304-3940(01)01844-4. Neurosci Lett. 2001. PMID: 11403936
-
Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia.Biol Psychiatry. 2004 Dec 15;56(12):943-50. doi: 10.1016/j.biopsych.2004.09.005. Biol Psychiatry. 2004. PMID: 15601604
-
GABA transporter-1 mRNA in the prefrontal cortex in schizophrenia: decreased expression in a subset of neurons.Am J Psychiatry. 2001 Feb;158(2):256-65. doi: 10.1176/appi.ajp.158.2.256. Am J Psychiatry. 2001. PMID: 11156808
-
Presynaptic proteins and schizophrenia.Int Rev Neurobiol. 2004;59:175-99. doi: 10.1016/S0074-7742(04)59007-4. Int Rev Neurobiol. 2004. PMID: 15006488 Review. No abstract available.
-
Translational and developmental perspective on N-methyl-D-aspartate synaptic deficits in schizophrenia.Dev Psychopathol. 2006 Summer;18(3):853-76. Dev Psychopathol. 2006. PMID: 17152404 Review.
Cited by
-
Intracortical excitatory and thalamocortical boutons are intact in primary auditory cortex in schizophrenia.Schizophr Res. 2013 Sep;149(1-3):127-34. doi: 10.1016/j.schres.2013.06.024. Epub 2013 Jul 2. Schizophr Res. 2013. PMID: 23830684 Free PMC article.
-
A decision-theory approach to interpretable set analysis for high-dimensional data.Biometrics. 2013 Sep;69(3):614-23. doi: 10.1111/biom.12060. Epub 2013 Aug 2. Biometrics. 2013. PMID: 23909925 Free PMC article.
-
Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia.PLoS One. 2012;7(4):e36351. doi: 10.1371/journal.pone.0036351. Epub 2012 Apr 27. PLoS One. 2012. PMID: 22558445 Free PMC article.
-
Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission.J Neurosci. 2004 Oct 6;24(40):8796-805. doi: 10.1523/JNEUROSCI.1940-04.2004. J Neurosci. 2004. PMID: 15470145 Free PMC article.
-
Psychogenomics: opportunities for understanding addiction.J Neurosci. 2001 Nov 1;21(21):8324-7. doi: 10.1523/JNEUROSCI.21-21-08324.2001. J Neurosci. 2001. PMID: 11606619 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
