Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Mar 2;291(5509):1755-9.
doi: 10.1126/science.1057206. Epub 2001 Feb 1.

An iron-regulated ferric reductase associated with the absorption of dietary iron

A T McKie  1 , D Barrow, G O Latunde-Dada, A Rolfs, G Sager, E Mudaly, M Mudaly, C Richardson, D Barlow, A Bomford, T J Peters, K B Raja, S Shirali, M A Hediger, F Farzaneh, R J Simpson
Affiliations

An iron-regulated ferric reductase associated with the absorption of dietary iron

A T McKie et al. Science. .

Abstract

The ability of intestinal mucosa to absorb dietary ferric iron is attributed to the presence of a brush-border membrane reductase activity that displays adaptive responses to iron status. We have isolated a complementary DNA, Dcytb (for duodenal cytochrome b), which encoded a putative plasma membrane di-heme protein in mouse duodenal mucosa. Dcytb shared between 45 and 50% similarity to the cytochrome b561 family of plasma membrane reductases, was highly expressed in the brush-border membrane of duodenal enterocytes, and induced ferric reductase activity when expressed in Xenopus oocytes and cultured cells. Duodenal expression levels of Dcytb messenger RNA and protein were regulated by changes in physiological modulators of iron absorption. Thus, Dcytb provides an important element in the iron absorption pathway.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

  NODES
admin 1
twitter 2