Review
doi: 10.1016/s0955-0674(00)00233-7.
ER quality control: towards an understanding at the molecular level
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- PMID: 11454449
- DOI: 10.1016/s0955-0674(00)00233-7
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Review
ER quality control: towards an understanding at the molecular level
Curr Opin Cell Biol.
2001 Aug.
Abstract
The process of 'quality control' in the endoplasmic reticulum (ER) involves a variety of mechanisms that collectively ensure that only correctly folded, assembled and modified proteins are transported along the secretory pathway. In contrast, non-native proteins are retained and eventually _targeted for degradation. Recent work provides the first structural insights into the process of glycoprotein folding in the ER involving the lectin chaperones calnexin and calreticulin. Underlying principles governing the choice of chaperone system engaged by different proteins have also been discovered.
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