doi: 10.1126/science.1064413.
Epub 2001 Aug 9.
Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus
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- PMID: 11498546
- DOI: 10.1126/science.1064413
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Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus
Science.
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Abstract
Methylation of histones at specific residues plays an important role in transcriptional regulation. Chromatin immunoprecipitation of dimethylated lysine 9 on histone H3 across 53 kilobases of the chicken beta-globin locus during erythropoiesis shows an almost complete anticorrelation between regions of elevated lysine 9 methylation and acetylation. Lysine 9 is methylated most over constitutive condensed chromatin and developmentally inactive globin genes. In contrast, lysine 4 methylation of histone H3 correlates with H3 acetylation. These results lead us to propose a mechanism by which the insulator in the beta-globin locus can protect the globin genes from being silenced by adjacent condensed chromatin.
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