Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF)
- PMID: 11532338
- DOI: 10.1016/s0169-328x(01)00183-8
Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF)
Abstract
Here we have studied the distribution of mRNA for tyrosine kinase B (trkB), the high-affinity receptor for brain-derived neurotrophic factor (BDNF) amongst serotonergic cell bodies of the raphe nuclei and their ascending projections into the dorsal hippocampus in the rat brain. Previous studies have shown that BDNF has got trophic action on serotonergic neurons. In the present study, we provide evidence that serotonergic neurons express mRNA for the functional receptor of BDNF, trkB. Intracerebro-ventricular (i.c.v.) injection of the 5-HT-specific neurotoxin, 5,7-dihydroxytryptamine, which lesions serotonergic cell bodies in the raphe nuclei as well as their ascending projections into the dorsal hippocampus, caused a dramatic loss of trkB mRNA from serotonergic cell bodies of the dorsal raphe nucleus. In contrast, there was no change in the abundance of trkB mRNA within the dorsal hippocampus. These findings provide direct evidence for the expression of trkB mRNA by serotonergic neurons and suggest distinct mechanisms of action of BDNF upon serotonergic neurons at the levels of their cell bodies and terminal projection sites.
Similar articles
-
Brain-derived neurotrophic factor and trkB are essential for cAMP-mediated induction of the serotonergic neuronal phenotype.J Neurosci Res. 2000 Aug 1;61(3):295-301. doi: 10.1002/1097-4547(20000801)61:3<295::AID-JNR7>3.0.CO;2-4. J Neurosci Res. 2000. PMID: 10900076
-
Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype.Mol Cell Neurosci. 2000 May;15(5):446-55. doi: 10.1006/mcne.2000.0841. Mol Cell Neurosci. 2000. PMID: 10833301
-
Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus.Synapse. 1994 May;17(1):1-15. doi: 10.1002/syn.890170102. Synapse. 1994. PMID: 8042142
-
Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice.Neuropharmacology. 2008 Nov;55(6):1006-14. doi: 10.1016/j.neuropharm.2008.08.001. Epub 2008 Aug 12. Neuropharmacology. 2008. PMID: 18761360 Review.
-
New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol's antidepressant effect.Prog Neuropsychopharmacol Biol Psychiatry. 2024 Jul 13;133:111029. doi: 10.1016/j.pnpbp.2024.111029. Epub 2024 May 16. Prog Neuropsychopharmacol Biol Psychiatry. 2024. PMID: 38762160 Review.
Cited by
-
_target identification for CNS diseases by transcriptional profiling.Neuropsychopharmacology. 2009 Jan;34(1):18-54. doi: 10.1038/npp.2008.172. Epub 2008 Oct 15. Neuropsychopharmacology. 2009. PMID: 18923405 Free PMC article. Review.
-
Antidepressant effects of novel positive allosteric modulators of Trk-receptor mediated signaling - a potential therapeutic concept?Psychopharmacology (Berl). 2023 Aug;240(8):1789-1804. doi: 10.1007/s00213-023-06410-x. Epub 2023 Jul 3. Psychopharmacology (Berl). 2023. PMID: 37394539 Free PMC article.
-
Central monoaminergic systems are a site of convergence of signals conveying the experience of exercise to brain circuits involved in cognition and emotional behavior.Curr Zool. 2016 Jun;62(3):293-306. doi: 10.1093/cz/zow027. Epub 2016 Mar 24. Curr Zool. 2016. PMID: 29491917 Free PMC article.
-
Treadmill exercise alters ecstasy- induced long- term potentiation disruption in the hippocampus of male rats.Metab Brain Dis. 2017 Oct;32(5):1603-1607. doi: 10.1007/s11011-017-0046-9. Epub 2017 Jun 13. Metab Brain Dis. 2017. PMID: 28612273
-
Neurotrophin receptor Ntrk2b function in the maintenance of dopamine and serotonin neurons in zebrafish.Sci Rep. 2019 Feb 14;9(1):2036. doi: 10.1038/s41598-019-39347-3. Sci Rep. 2019. PMID: 30765816 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
