Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF)
- PMID: 11532338
- DOI: 10.1016/s0169-328x(01)00183-8
Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine kinase B (trkB), the high-affinity receptor for brain derived neurotrophic factor (BDNF)
Abstract
Here we have studied the distribution of mRNA for tyrosine kinase B (trkB), the high-affinity receptor for brain-derived neurotrophic factor (BDNF) amongst serotonergic cell bodies of the raphe nuclei and their ascending projections into the dorsal hippocampus in the rat brain. Previous studies have shown that BDNF has got trophic action on serotonergic neurons. In the present study, we provide evidence that serotonergic neurons express mRNA for the functional receptor of BDNF, trkB. Intracerebro-ventricular (i.c.v.) injection of the 5-HT-specific neurotoxin, 5,7-dihydroxytryptamine, which lesions serotonergic cell bodies in the raphe nuclei as well as their ascending projections into the dorsal hippocampus, caused a dramatic loss of trkB mRNA from serotonergic cell bodies of the dorsal raphe nucleus. In contrast, there was no change in the abundance of trkB mRNA within the dorsal hippocampus. These findings provide direct evidence for the expression of trkB mRNA by serotonergic neurons and suggest distinct mechanisms of action of BDNF upon serotonergic neurons at the levels of their cell bodies and terminal projection sites.
Similar articles
-
Brain-derived neurotrophic factor and trkB are essential for cAMP-mediated induction of the serotonergic neuronal phenotype.J Neurosci Res. 2000 Aug 1;61(3):295-301. doi: 10.1002/1097-4547(20000801)61:3<295::AID-JNR7>3.0.CO;2-4. J Neurosci Res. 2000. PMID: 10900076
-
Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype.Mol Cell Neurosci. 2000 May;15(5):446-55. doi: 10.1006/mcne.2000.0841. Mol Cell Neurosci. 2000. PMID: 10833301
-
Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus.Synapse. 1994 May;17(1):1-15. doi: 10.1002/syn.890170102. Synapse. 1994. PMID: 8042142
-
Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice.Neuropharmacology. 2008 Nov;55(6):1006-14. doi: 10.1016/j.neuropharm.2008.08.001. Epub 2008 Aug 12. Neuropharmacology. 2008. PMID: 18761360 Review.
-
New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol's antidepressant effect.Prog Neuropsychopharmacol Biol Psychiatry. 2024 Jul 13;133:111029. doi: 10.1016/j.pnpbp.2024.111029. Epub 2024 May 16. Prog Neuropsychopharmacol Biol Psychiatry. 2024. PMID: 38762160 Review.
Cited by
-
Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function.Mol Pharmacol. 2012 Jan;81(1):73-85. doi: 10.1124/mol.111.073171. Epub 2011 Oct 12. Mol Pharmacol. 2012. PMID: 21992875 Free PMC article.
-
Alcohol induced depressive-like behavior is associated with a reduction in hippocampal BDNF.Pharmacol Biochem Behav. 2011 Dec;100(2):253-8. doi: 10.1016/j.pbb.2011.08.014. Epub 2011 Sep 10. Pharmacol Biochem Behav. 2011. PMID: 21930150 Free PMC article.
-
Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus.Neuroscience. 2013 Dec 19;254:160-72. doi: 10.1016/j.neuroscience.2013.08.071. Epub 2013 Sep 20. Neuroscience. 2013. PMID: 24055683 Free PMC article.
-
Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test.Sci Rep. 2017 Oct 18;7(1):13515. doi: 10.1038/s41598-017-14069-6. Sci Rep. 2017. PMID: 29044198 Free PMC article.
-
Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.Neuroscience. 2012 Nov 8;224:125-34. doi: 10.1016/j.neuroscience.2012.08.025. Epub 2012 Aug 21. Neuroscience. 2012. PMID: 22917617 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
