The selective mGlu(5) receptor agonist CHPG inhibits quinpirole-induced turning in 6-hydroxydopamine-lesioned rats and modulates the binding characteristics of dopamine D(2) receptors in the rat striatum: interactions with adenosine A(2a) receptors
- PMID: 11557164
- DOI: 10.1016/S0893-133X(01)00256-1
The selective mGlu(5) receptor agonist CHPG inhibits quinpirole-induced turning in 6-hydroxydopamine-lesioned rats and modulates the binding characteristics of dopamine D(2) receptors in the rat striatum: interactions with adenosine A(2a) receptors
Abstract
In 6-hydroxydopamine-lesioned rats, the selective mGlu(5) receptor agonist (RS)-2-Cholro-5-Hydroxyphenylglycine (CHPG, 1-6 microg/10 microl intracerebroventricularly) significantly inhibited contralateral turning induced by quinpirole and, to a lesser extent, that induced by SKF 38393. The inhibitory effects of CHPG on quinpirole-induced turning were significantly potentiated by an adenosine A(2A) receptor agonist (CGS 21680, 0.2 mg/kg IP) and attenuated by an A(2A) receptor antagonist (SCH 58261, 1 mg/kg IP). In rat striatal membranes, CHPG (100-1,000 nM) significantly reduced the affinity of the high-affinity state of D(2) receptors for the agonist, an effect potentiated by CGS 21680 (30 nM). These results show the occurrence of functional interactions among mGlu(5), adenosine A(2A), and dopamine D(2) receptors in the regulation of striatal functioning, and suggest that mGlu(5) receptors may be regarded as alternative/integrative _targets for the development of therapeutic strategies in the treatment of Parkinson's disease.
Similar articles
-
Adenosine A2A and group I metabotropic glutamate receptors synergistically modulate the binding characteristics of dopamine D2 receptors in the rat striatum.Neuropharmacology. 1999 Jan;38(1):129-40. doi: 10.1016/s0028-3908(98)00154-3. Neuropharmacology. 1999. PMID: 10193904
-
Blockade of globus pallidus adenosine A(2A) receptors displays antiparkinsonian activity in 6-hydroxydopamine-lesioned rats treated with D(1) or D(2) dopamine receptor agonists.Synapse. 2008 May;62(5):345-51. doi: 10.1002/syn.20504. Synapse. 2008. PMID: 18297692
-
Role of striatal acetylcholine on dopamine D1 receptor agonist-induced turning behavior in 6-hydroxydopamine lesioned rats: a microdialysis-behavioral study.Neurol Sci. 2001 Feb;22(1):63-4. doi: 10.1007/s100720170048. Neurol Sci. 2001. PMID: 11487203
-
Dopamine/glutamate interaction as studied by combining turning behaviour and c-Fos expression.Neurosci Biobehav Rev. 1997 Jul;21(4):505-9. doi: 10.1016/s0149-7634(96)00031-0. Neurosci Biobehav Rev. 1997. PMID: 9195609 Review.
-
Evidence for adenosine/dopamine receptor interactions: indications for heteromerization.Neuropsychopharmacology. 2000 Oct;23(4 Suppl):S50-9. doi: 10.1016/S0893-133X(00)00144-5. Neuropsychopharmacology. 2000. PMID: 11008067 Review.
Cited by
-
Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1322-7. doi: 10.1073/pnas.0237126100. Epub 2003 Jan 21. Proc Natl Acad Sci U S A. 2003. PMID: 12538871 Free PMC article.
-
Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats.Neuroscience. 2009 Nov 10;163(4):1171-80. doi: 10.1016/j.neuroscience.2009.07.060. Epub 2009 Aug 4. Neuroscience. 2009. PMID: 19660528 Free PMC article.
-
Modulation of mGlu5 reduces rewarding associative properties of nicotine via changes in mesolimbic plasticity: Relevance to comorbid cigarette smoking in psychosis.Pharmacol Biochem Behav. 2024 Jun;239:173752. doi: 10.1016/j.pbb.2024.173752. Epub 2024 Mar 21. Pharmacol Biochem Behav. 2024. PMID: 38521210
-
mGlu5 Receptor Functional Interactions and Addiction.Front Pharmacol. 2012 May 7;3:84. doi: 10.3389/fphar.2012.00084. eCollection 2012. Front Pharmacol. 2012. PMID: 22586398 Free PMC article.
-
Disease-specific heteromerization of G-protein-coupled receptors that _target drugs of abuse.Prog Mol Biol Transl Sci. 2013;117:207-65. doi: 10.1016/B978-0-12-386931-9.00009-X. Prog Mol Biol Transl Sci. 2013. PMID: 23663971 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
