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. 2001 Nov 2;107(3):323-37.
doi: 10.1016/s0092-8674(01)00542-6.

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

A H Peters  1 , D O'Carroll, H Scherthan, K Mechtler, S Sauer, C Schöfer, K Weipoltshammer, M Pagani, M Lachner, A Kohlmaier, S Opravil, M Doyle, M Sibilia, T Jenuwein
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Free article

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

A H Peters et al. Cell. .
Free article

Abstract

Histone H3 lysine 9 methylation has been proposed to provide a major "switch" for the functional organization of chromosomal subdomains. Here, we show that the murine Suv39h histone methyltransferases (HMTases) govern H3-K9 methylation at pericentric heterochromatin and induce a specialized histone methylation pattern that differs from the broad H3-K9 methylation present at other chromosomal regions. Suv39h-deficient mice display severely impaired viability and chromosomal instabilities that are associated with an increased tumor risk and perturbed chromosome interactions during male meiosis. These in vivo data assign a crucial role for pericentric H3-K9 methylation in protecting genome stability, and define the Suv39h HMTases as important epigenetic regulators for mammalian development.

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