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Review
. 2001 Dec;11(6):725-32.
doi: 10.1016/s0959-440x(01)00266-4.

The leucine-rich repeat as a protein recognition motif

B Kobe  1 , A V Kajava
Affiliations
Review

The leucine-rich repeat as a protein recognition motif

B Kobe et al. Curr Opin Struct Biol. 2001 Dec.

Abstract

Leucine-rich repeats (LRRs) are 20-29-residue sequence motifs present in a number of proteins with diverse functions. The primary function of these motifs appears to be to provide a versatile structural framework for the formation of protein-protein interactions. The past two years have seen an explosion of new structural information on proteins with LRRs. The new structures represent different LRR subfamilies and proteins with diverse functions, including GTPase-activating protein rna1p from the ribonuclease-inhibitor-like subfamily; spliceosomal protein U2A', Rab geranylgeranyltransferase, internalin B, dynein light chain 1 and nuclear export protein TAP from the SDS22-like subfamily; Skp2 from the cysteine-containing subfamily; and YopM from the bacterial subfamily. The new structural information has increased our understanding of the structural determinants of LRR proteins and our ability to model such proteins with unknown structures, and has shed new light on how these proteins participate in protein-protein interactions.

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