Review
doi: 10.1016/s0959-437x(02)00290-3.
RNAi: nature abhors a double-strand
Affiliations
- PMID: 11893497
- DOI: 10.1016/s0959-437x(02)00290-3
Item in Clipboard
Review
RNAi: nature abhors a double-strand
Curr Opin Genet Dev.
2002 Apr.
Abstract
In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA _targets.
Similar articles
-
A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst.Cell. 2001 Nov 16;107(4):415-8. doi: 10.1016/s0092-8674(01)00581-5. Cell. 2001. PMID: 11719182 Review.
-
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells.Nature. 2000 Mar 16;404(6775):293-6. doi: 10.1038/35005107. Nature. 2000. PMID: 10749213
-
Role for a bidentate ribonuclease in the initiation step of RNA interference.Nature. 2001 Jan 18;409(6818):363-6. doi: 10.1038/35053110. Nature. 2001. PMID: 11201747
-
[Physiological and technological aspects of RNAi].Tanpakushitsu Kakusan Koso. 2003 Mar;48(4 Suppl):469-79. Tanpakushitsu Kakusan Koso. 2003. PMID: 12696156 Review. Japanese. No abstract available.
-
Ancient pathways programmed by small RNAs.Science. 2002 May 17;296(5571):1265-9. doi: 10.1126/science.1072457. Science. 2002. PMID: 12016303
Cited by
-
Circadian disruption and breast cancer: an epigenetic link?Onco_target. 2015 Jul 10;6(19):16866-82. doi: 10.18632/onco_target.4343. Onco_target. 2015. PMID: 26220712 Free PMC article. Review.
-
Vitellogenin knockdown strongly affects cotton boll weevil egg viability but not the number of eggs laid by females.Meta Gene. 2016 Jun 25;9:173-80. doi: 10.1016/j.mgene.2016.06.005. eCollection 2016 Sep. Meta Gene. 2016. PMID: 27419079 Free PMC article.
-
High potency silencing by single-stranded boranophosphate siRNA.Nucleic Acids Res. 2006 May 22;34(9):2773-81. doi: 10.1093/nar/gkl339. Print 2006. Nucleic Acids Res. 2006. PMID: 16717282 Free PMC article.
-
The mammalian transcriptome and the function of non-coding DNA sequences.Genome Biol. 2004;5(4):105. doi: 10.1186/gb-2004-5-4-105. Epub 2004 Mar 25. Genome Biol. 2004. PMID: 15059247 Free PMC article. Review.
-
Slicer function of Drosophila Argonautes and its involvement in RISC formation.Genes Dev. 2005 Dec 1;19(23):2837-48. doi: 10.1101/gad.1370605. Epub 2005 Nov 14. Genes Dev. 2005. PMID: 16287716 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
